Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells

Hyun Jong Lee; Sangphil Park; Eunji Jang; Tae Geuk Lim; Sang Won Han; Hyue Won Lee; Ui Seok Chung; Won Gun Koh

Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells

Hyun Jong Lee, Sangphil Park, Eunji Jang, Tae Geuk Lim, Sang Won Han, Hyue Won Lee, Ui Seok Chung, Won Gun Koh

Department of Chemical and Biomolecular Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

To mimic the actual microenvironment, independent release control of some growth factors is required in tissue engineering field. Here, we fabricated multifunctional nanofiber-based three dimensional (3D) cell scaffolds which have the capability of release of growth factors independently. From the osteogenesis differentiation of hMSC cultured on the fabricated scaffolds, the capacity as a tissue engineering scaffold was demonstrated successfully. We expect that this independently controlled release system has a great potential for tissue engineering, biochip and other biomedical fields.

Original language	English
Title of host publication	Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Publisher	Chemical and Biological Microsystems Society
Pages	1705-1707
Number of pages	3
ISBN (Print)	9780979806452
Publication status	Published - 2012
Event	16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan Duration: 2012 Oct 28 → 2012 Nov 1

Publication series

Name	Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other	16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country	Japan
City	Okinawa
Period	12/10/28 → 12/11/1

All Science Journal Classification (ASJC) codes

Chemical Engineering (miscellaneous)
Bioengineering

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Lee, H. J., Park, S., Jang, E., Lim, T. G., Won Han, S., Won Lee, H., Chung, U. S., & Koh, W. G. (2012). Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1705-1707). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.

Lee, Hyun Jong ; Park, Sangphil ; Jang, Eunji ; Lim, Tae Geuk ; Won Han, Sang ; Won Lee, Hyue ; Chung, Ui Seok ; Koh, Won Gun. / Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. pp. 1705-1707 (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).

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title = "Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells",

abstract = "To mimic the actual microenvironment, independent release control of some growth factors is required in tissue engineering field. Here, we fabricated multifunctional nanofiber-based three dimensional (3D) cell scaffolds which have the capability of release of growth factors independently. From the osteogenesis differentiation of hMSC cultured on the fabricated scaffolds, the capacity as a tissue engineering scaffold was demonstrated successfully. We expect that this independently controlled release system has a great potential for tissue engineering, biochip and other biomedical fields.",

author = "Lee, {Hyun Jong} and Sangphil Park and Eunji Jang and Lim, {Tae Geuk} and {Won Han}, Sang and {Won Lee}, Hyue and Chung, {Ui Seok} and Koh, {Won Gun}",

year = "2012",

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isbn = "9780979806452",

series = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",

publisher = "Chemical and Biological Microsystems Society",

pages = "1705--1707",

booktitle = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",

note = "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 ; Conference date: 28-10-2012 Through 01-11-2012",

}

Lee, HJ, Park, S, Jang, E, Lim, TG, Won Han, S, Won Lee, H, Chung, US & Koh, WG 2012, Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells. in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Chemical and Biological Microsystems Society, pp. 1705-1707, 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Okinawa, Japan, 12/10/28.

Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells. / Lee, Hyun Jong; Park, Sangphil; Jang, Eunji; Lim, Tae Geuk; Won Han, Sang; Won Lee, Hyue; Chung, Ui Seok; Koh, Won Gun.

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. p. 1705-1707 (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Lim, Tae Geuk

AU - Won Han, Sang

AU - Won Lee, Hyue

AU - Chung, Ui Seok

AU - Koh, Won Gun

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AB - To mimic the actual microenvironment, independent release control of some growth factors is required in tissue engineering field. Here, we fabricated multifunctional nanofiber-based three dimensional (3D) cell scaffolds which have the capability of release of growth factors independently. From the osteogenesis differentiation of hMSC cultured on the fabricated scaffolds, the capacity as a tissue engineering scaffold was demonstrated successfully. We expect that this independently controlled release system has a great potential for tissue engineering, biochip and other biomedical fields.

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BT - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

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Lee HJ, Park S, Jang E, Lim TG, Won Han S, Won Lee H et al. Distinct releases of growth factors from three dimensional fibrous scaffolds combined with hydrogel for differentiation of mesenchymal stem cells. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society. 2012. p. 1705-1707. (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).