Distinctive Nanogels as High-Efficiency Transdermal Carriers for Skin Wound Healing

Seong Uk Son, Soojin Jang, Yuna Choi, Mirae Park, Hye Young Son, Yong Min Huh, Soo Jin Yeom, Moon Sun Ham, Do Kyung Lee, Han Na Kim, Yeung Bae Jin, Taejoon Kang, Juyeon Jung, Eun Kyung Lim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We propose that nanogels (HLGs) prepared by simply blending an epidermal growth factor (EGF)-loaded hyaluronan (HA)-based nanoformulation and poloxamers can be efficient transdermal drug carriers. In particular, due to the thermogelling behavior of poloxamer, when the HLGs, which are liquid at room temperature, are applied to the skin's surface, they form a gel at skin temperature. First, lipid-based nanoformulations (EGF-LNs) were fabricated by the lipid thin film method and then chemically conjugated with HA on the surface of the films to prepare EGF-loaded HA-based nanoformulations (EGF-HLNs). Both EGF-LNs and EGF-HLNs exhibited a uniform size and spherical lamellar structure. The EGF-HLN was added to a poloxamer solution to form EGF-HLG, which is a liquid at room temperature and a gel at skin temperature. HLGs have been shown to be able to deliver and permeate EGF well into the skin using both in vitro and in vivo systems, thus serving as an effective transdermal delivery system. In addition, it has been confirmed that this system could be a possible implantable drug carrier. Therefore, HLGs, which are uncomplicated and easily prepared, are expected to be easily used not only in the pharmaceutical field but also in the cosmetic field.

Original languageEnglish
Pages (from-to)304-314
Number of pages11
JournalJournal of Biomedical Nanotechnology
Issue number3
Publication statusPublished - 2020 Mar 1

Bibliographical note

Funding Information:
NRN acknowledges financial support from the European Union Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 721463 to the SUNDIAL ITN network. CT is supported through an NWO-VICI grant (project number 639.043.308). Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme IDs 177.A-3016, 177.A-3017 and 177.A-3018, and on data products produced by Target/OmegaCEN, INAF-OACN, INAF-OAPD and the KiDS production team, on behalf of the KiDS consortium. OmegaCEN and the KiDS production team acknowledge support by NOVA and NWO-M grants. Members of INAF- OAPD and INAF-OACN also acknowledge the support from the Department of Physics and Astronomy of the University of Padova, and of the Department of Physics of University Federico II (Naples). We thank Giuseppe D’Ago for useful discussions and feedback on the analysis performed in this paper.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science


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