TY - JOUR
T1 - Distribution of ADH2 and ALDH2 genotypes in different populations
AU - Goedde, H. W.
AU - Agarwal, D. P.
AU - Fritze, G.
AU - Meier-Tackmann, D.
AU - Singh, S.
AU - Beckmann, G.
AU - Bhatia, K.
AU - Chen, L. Z.
AU - Fang, B.
AU - Lisker, R.
AU - Paik, Y. K.
AU - Rothhammer, F.
AU - Saha, N.
AU - Segal, B.
AU - Srivastava, L. M.
AU - Czeizel, A.
PY - 1992/1
Y1 - 1992/1
N2 - The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.
AB - The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.
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U2 - 10.1007/BF00197271
DO - 10.1007/BF00197271
M3 - Article
C2 - 1733836
AN - SCOPUS:0026609541
VL - 88
SP - 344
EP - 346
JO - Human Genetics
JF - Human Genetics
SN - 0340-6717
IS - 3
ER -
