Distribution of ADH2 and ALDH2 genotypes in different populations

H. W. Goedde, D. P. Agarwal, G. Fritze, D. Meier-Tackmann, S. Singh, G. Beckmann, K. Bhatia, L. Z. Chen, B. Fang, R. Lisker, Y. K. Paik, F. Rothhammer, N. Saha, B. Segal, L. M. Srivastava, A. Czeizel

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Abstract

The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

Original languageEnglish
Pages (from-to)344-346
Number of pages3
JournalHuman Genetics
Volume88
Issue number3
DOIs
Publication statusPublished - 1992 Jan

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Oceanic Ancestry Group
Genotype
Alcohols
Population
Genes
Nucleic Acid Hybridization
Aldehyde Dehydrogenase
Oligonucleotide Probes
Alcohol Dehydrogenase
Chile
Alcoholism
Liver Diseases
Alleles
Liver
DNA

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Goedde, H. W., Agarwal, D. P., Fritze, G., Meier-Tackmann, D., Singh, S., Beckmann, G., ... Czeizel, A. (1992). Distribution of ADH2 and ALDH2 genotypes in different populations. Human Genetics, 88(3), 344-346. https://doi.org/10.1007/BF00197271
Goedde, H. W. ; Agarwal, D. P. ; Fritze, G. ; Meier-Tackmann, D. ; Singh, S. ; Beckmann, G. ; Bhatia, K. ; Chen, L. Z. ; Fang, B. ; Lisker, R. ; Paik, Y. K. ; Rothhammer, F. ; Saha, N. ; Segal, B. ; Srivastava, L. M. ; Czeizel, A. / Distribution of ADH2 and ALDH2 genotypes in different populations. In: Human Genetics. 1992 ; Vol. 88, No. 3. pp. 344-346.
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Goedde, HW, Agarwal, DP, Fritze, G, Meier-Tackmann, D, Singh, S, Beckmann, G, Bhatia, K, Chen, LZ, Fang, B, Lisker, R, Paik, YK, Rothhammer, F, Saha, N, Segal, B, Srivastava, LM & Czeizel, A 1992, 'Distribution of ADH2 and ALDH2 genotypes in different populations', Human Genetics, vol. 88, no. 3, pp. 344-346. https://doi.org/10.1007/BF00197271

Distribution of ADH2 and ALDH2 genotypes in different populations. / Goedde, H. W.; Agarwal, D. P.; Fritze, G.; Meier-Tackmann, D.; Singh, S.; Beckmann, G.; Bhatia, K.; Chen, L. Z.; Fang, B.; Lisker, R.; Paik, Y. K.; Rothhammer, F.; Saha, N.; Segal, B.; Srivastava, L. M.; Czeizel, A.

In: Human Genetics, Vol. 88, No. 3, 01.1992, p. 344-346.

Research output: Contribution to journalArticle

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T1 - Distribution of ADH2 and ALDH2 genotypes in different populations

AU - Goedde, H. W.

AU - Agarwal, D. P.

AU - Fritze, G.

AU - Meier-Tackmann, D.

AU - Singh, S.

AU - Beckmann, G.

AU - Bhatia, K.

AU - Chen, L. Z.

AU - Fang, B.

AU - Lisker, R.

AU - Paik, Y. K.

AU - Rothhammer, F.

AU - Saha, N.

AU - Segal, B.

AU - Srivastava, L. M.

AU - Czeizel, A.

PY - 1992/1

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N2 - The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

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Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G et al. Distribution of ADH2 and ALDH2 genotypes in different populations. Human Genetics. 1992 Jan;88(3):344-346. https://doi.org/10.1007/BF00197271