Distribution of ADH2 and ALDH2 genotypes in different populations

H. W. Goedde; D. P. Agarwal; G. Fritze; D. Meier-Tackmann; S. Singh; G. Beckmann; K. Bhatia; L. Z. Chen; B. Fang; R. Lisker; Y. K. Paik; F. Rothhammer; N. Saha; B. Segal; L. M. Srivastava; A. Czeizel

doi:10.1007/BF00197271

Distribution of ADH₂ and ALDH2 genotypes in different populations

H. W. Goedde, D. P. Agarwal, G. Fritze, D. Meier-Tackmann, S. Singh, G. Beckmann, K. Bhatia, L. Z. Chen, B. Fang, R. Lisker, Y. K. Paik, F. Rothhammer, N. Saha, B. Segal, L. M. Srivastava, A. Czeizel

Research output: Contribution to journal › Article › peer-review

440 Citations (Scopus)

Abstract

The distribution of the human liver alcohol dehydrogenase, ADH₂, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH₁ ²allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH₂ ²gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH2²) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

Original language	English
Pages (from-to)	344-346
Number of pages	3
Journal	Human Genetics
Volume	88
Issue number	3
DOIs	https://doi.org/10.1007/BF00197271
Publication status	Published - 1992 Jan

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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@article{009ac5c1f4214087a83fe34b6a1e759f,

title = "Distribution of ADH2 and ALDH2 genotypes in different populations",

abstract = "The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.",

author = "Goedde, {H. W.} and Agarwal, {D. P.} and G. Fritze and D. Meier-Tackmann and S. Singh and G. Beckmann and K. Bhatia and Chen, {L. Z.} and B. Fang and R. Lisker and Paik, {Y. K.} and F. Rothhammer and N. Saha and B. Segal and Srivastava, {L. M.} and A. Czeizel",

year = "1992",

month = jan,

doi = "10.1007/BF00197271",

language = "English",

volume = "88",

pages = "344--346",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Verlag",

number = "3",

}

Distribution of ADH₂ and ALDH2 genotypes in different populations. / Goedde, H. W.; Agarwal, D. P.; Fritze, G.; Meier-Tackmann, D.; Singh, S.; Beckmann, G.; Bhatia, K.; Chen, L. Z.; Fang, B.; Lisker, R.; Paik, Y. K.; Rothhammer, F.; Saha, N.; Segal, B.; Srivastava, L. M.; Czeizel, A.

In: Human Genetics, Vol. 88, No. 3, 01.1992, p. 344-346.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Distribution of ADH2 and ALDH2 genotypes in different populations

AU - Goedde, H. W.

AU - Agarwal, D. P.

AU - Fritze, G.

AU - Meier-Tackmann, D.

AU - Singh, S.

AU - Beckmann, G.

AU - Bhatia, K.

AU - Chen, L. Z.

AU - Fang, B.

AU - Lisker, R.

AU - Paik, Y. K.

AU - Rothhammer, F.

AU - Saha, N.

AU - Segal, B.

AU - Srivastava, L. M.

AU - Czeizel, A.

PY - 1992/1

Y1 - 1992/1

N2 - The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

AB - The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

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