Distribution of cerebral microbleeds determines their association with impaired kidney function

Tae Jin Song, Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Jihoe Heo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and Purposezz Cerebral microbleeds (CMBs)are associated with various pathologies of the cerebral small vessels according to their distribution (i.e., cerebral amyloid angiopathy or hypertensive angiopathy). We investigated the association between CMB location and kidney function in acute ischemic stroke patients. Methodszz We enrolled 1669 consecutive patients with acute ischemic stroke who underwent gradient-recalled echo brain magnetic resonance imaging. Kidney function was determined using the estimated glomerular filtration rate (eGFR). CMBs were classified into strictly lobar, strictly nonlobar (i.e., only deep or infratentorial), and a combination of both lobar and nonlobar. Multinomial logistic regression analyses were used to determine the factors associated with the existence of CMBs according to their location. ResultszzThe patients were aged 66±12 years (mean±standard deviation), and 61.9% (1033/ 1669)of them were male. CMBs were found in 27.0% (452/1669)of the patients. The stroke subtypes of small-artery occlusion and cardioembolism occurred more frequently in those with strictly nonlobar CMBs (10.8%)and strictly lobar CMBs (48.8%), respectively. The mean eGFR was lower in the strictly nonlobar CMBs group (72±28 mL/min/1.73 m2)and the both lobar and nonlobar CMBs group (72±25 mL/min/1.73 m2)than in the no-CMBs group (86±29 mL/ min/1.73 m2). Multivariate multinomial logistic regression revealed that eGFR <60 mL/min/1.73 m2 was independently related to strictly nonlobar CMBs (odds ratio=2.63, p=0.001). ConclusionszzImpaired kidney function is associated with strictly nonlobar CMBs. Our findings indicate that the distribution of CMBs should be considered when evaluating their relationships or prognoses.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalJournal of Clinical Neurology (Korea)
Volume10
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Glomerular Filtration Rate
Kidney
Stroke
Logistic Models
Cerebral Amyloid Angiopathy
Arteries
Odds Ratio
Regression Analysis
Magnetic Resonance Imaging
Pathology
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neurology

Cite this

Song, Tae Jin ; Kim, Jinkwon ; Lee, Hye Sun ; Nam, Chung Mo ; Nam, Hyo Suk ; Kim, Young Dae ; Heo, Jihoe. / Distribution of cerebral microbleeds determines their association with impaired kidney function. In: Journal of Clinical Neurology (Korea). 2014 ; Vol. 10, No. 3. pp. 222-228.
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title = "Distribution of cerebral microbleeds determines their association with impaired kidney function",
abstract = "Background and Purposezz Cerebral microbleeds (CMBs)are associated with various pathologies of the cerebral small vessels according to their distribution (i.e., cerebral amyloid angiopathy or hypertensive angiopathy). We investigated the association between CMB location and kidney function in acute ischemic stroke patients. Methodszz We enrolled 1669 consecutive patients with acute ischemic stroke who underwent gradient-recalled echo brain magnetic resonance imaging. Kidney function was determined using the estimated glomerular filtration rate (eGFR). CMBs were classified into strictly lobar, strictly nonlobar (i.e., only deep or infratentorial), and a combination of both lobar and nonlobar. Multinomial logistic regression analyses were used to determine the factors associated with the existence of CMBs according to their location. ResultszzThe patients were aged 66±12 years (mean±standard deviation), and 61.9{\%} (1033/ 1669)of them were male. CMBs were found in 27.0{\%} (452/1669)of the patients. The stroke subtypes of small-artery occlusion and cardioembolism occurred more frequently in those with strictly nonlobar CMBs (10.8{\%})and strictly lobar CMBs (48.8{\%}), respectively. The mean eGFR was lower in the strictly nonlobar CMBs group (72±28 mL/min/1.73 m2)and the both lobar and nonlobar CMBs group (72±25 mL/min/1.73 m2)than in the no-CMBs group (86±29 mL/ min/1.73 m2). Multivariate multinomial logistic regression revealed that eGFR <60 mL/min/1.73 m2 was independently related to strictly nonlobar CMBs (odds ratio=2.63, p=0.001). ConclusionszzImpaired kidney function is associated with strictly nonlobar CMBs. Our findings indicate that the distribution of CMBs should be considered when evaluating their relationships or prognoses.",
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Distribution of cerebral microbleeds determines their association with impaired kidney function. / Song, Tae Jin; Kim, Jinkwon; Lee, Hye Sun; Nam, Chung Mo; Nam, Hyo Suk; Kim, Young Dae; Heo, Jihoe.

In: Journal of Clinical Neurology (Korea), Vol. 10, No. 3, 01.01.2014, p. 222-228.

Research output: Contribution to journalArticle

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T1 - Distribution of cerebral microbleeds determines their association with impaired kidney function

AU - Song, Tae Jin

AU - Kim, Jinkwon

AU - Lee, Hye Sun

AU - Nam, Chung Mo

AU - Nam, Hyo Suk

AU - Kim, Young Dae

AU - Heo, Jihoe

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N2 - Background and Purposezz Cerebral microbleeds (CMBs)are associated with various pathologies of the cerebral small vessels according to their distribution (i.e., cerebral amyloid angiopathy or hypertensive angiopathy). We investigated the association between CMB location and kidney function in acute ischemic stroke patients. Methodszz We enrolled 1669 consecutive patients with acute ischemic stroke who underwent gradient-recalled echo brain magnetic resonance imaging. Kidney function was determined using the estimated glomerular filtration rate (eGFR). CMBs were classified into strictly lobar, strictly nonlobar (i.e., only deep or infratentorial), and a combination of both lobar and nonlobar. Multinomial logistic regression analyses were used to determine the factors associated with the existence of CMBs according to their location. ResultszzThe patients were aged 66±12 years (mean±standard deviation), and 61.9% (1033/ 1669)of them were male. CMBs were found in 27.0% (452/1669)of the patients. The stroke subtypes of small-artery occlusion and cardioembolism occurred more frequently in those with strictly nonlobar CMBs (10.8%)and strictly lobar CMBs (48.8%), respectively. The mean eGFR was lower in the strictly nonlobar CMBs group (72±28 mL/min/1.73 m2)and the both lobar and nonlobar CMBs group (72±25 mL/min/1.73 m2)than in the no-CMBs group (86±29 mL/ min/1.73 m2). Multivariate multinomial logistic regression revealed that eGFR <60 mL/min/1.73 m2 was independently related to strictly nonlobar CMBs (odds ratio=2.63, p=0.001). ConclusionszzImpaired kidney function is associated with strictly nonlobar CMBs. Our findings indicate that the distribution of CMBs should be considered when evaluating their relationships or prognoses.

AB - Background and Purposezz Cerebral microbleeds (CMBs)are associated with various pathologies of the cerebral small vessels according to their distribution (i.e., cerebral amyloid angiopathy or hypertensive angiopathy). We investigated the association between CMB location and kidney function in acute ischemic stroke patients. Methodszz We enrolled 1669 consecutive patients with acute ischemic stroke who underwent gradient-recalled echo brain magnetic resonance imaging. Kidney function was determined using the estimated glomerular filtration rate (eGFR). CMBs were classified into strictly lobar, strictly nonlobar (i.e., only deep or infratentorial), and a combination of both lobar and nonlobar. Multinomial logistic regression analyses were used to determine the factors associated with the existence of CMBs according to their location. ResultszzThe patients were aged 66±12 years (mean±standard deviation), and 61.9% (1033/ 1669)of them were male. CMBs were found in 27.0% (452/1669)of the patients. The stroke subtypes of small-artery occlusion and cardioembolism occurred more frequently in those with strictly nonlobar CMBs (10.8%)and strictly lobar CMBs (48.8%), respectively. The mean eGFR was lower in the strictly nonlobar CMBs group (72±28 mL/min/1.73 m2)and the both lobar and nonlobar CMBs group (72±25 mL/min/1.73 m2)than in the no-CMBs group (86±29 mL/ min/1.73 m2). Multivariate multinomial logistic regression revealed that eGFR <60 mL/min/1.73 m2 was independently related to strictly nonlobar CMBs (odds ratio=2.63, p=0.001). ConclusionszzImpaired kidney function is associated with strictly nonlobar CMBs. Our findings indicate that the distribution of CMBs should be considered when evaluating their relationships or prognoses.

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