Distribution of lymphoid neoplasms in the Republic of Korea

Analysis of 5318 cases according to the World Health Organization classification

SunOch Yoon, Cheolwon Suh, Dae Ho Lee, Hyun Sook Chi, Chan Jeoung Park, Seong Soo Jang, Hai Rim Shin, Bong Hee Park, Jooryung Huh

Research output: Contribution to journalArticle

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Abstract

Compared with the West, the overall incidence of lymphoid neoplasms is lower, and the subtype distribution is distinct in Asia. To comprehensively investigate the subtype distribution with the age and sex factors, and temporal changes of subtype proportions, we re-assessed all patients with lymphoid neoplasms diagnosed at a large oncology service in the Republic of Korea from 1989 to 2008 using the World Health Organization classifications. Of the total 5,318 patients, 66.9% had mature B-cell neoplasms, 12.5% had mature T/natural killer (NK)-cell neoplasms, 16.4% had precursor lymphoblastic leukemia/lymphoma (ALL/LBL), and 4.1% had Hodgkin's lymphoma. The most common subtypes were diffuse large B-cell lymphoma (30.5%), plasma cell myeloma (14.0%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma; 12.4%), B-cell ALL/LBL (11.3%), Hodgkin's lymphoma (4.1%), peripheral T-cell lymphoma unspecified (4.0%), T-cell ALL/LBL (3.9%), and extranodal NK/T-cell lymphoma of nasal type (3.9%). Most subtypes showed male predominance, with an average M/F ratio of 1.3. Most mature lymphoid neoplasms were diseases of adults (mean age, 53.5 yr), whereas ALL/LBLs were of young individuals (mean age, 20.3 yr). When the relative proportion of subtypes were compared between two decades (1989-1998 vs. 1999-2008), especially MALT lymphoma has increased in proportion, whereas T/NK-cell neoplasms and ALL/LBL have slightly decreased. In summary, the lymphoid neoplasms of Koreans shared some epidemiologic features similar to those of other countries, whereas some subtypes showed distinct features. Although the increase in incidence of lymphoid neoplasms is relatively modest in Korea, recent increase of MALT lymphoma and decrease of T/NK-cell neoplasms and ALL/LBL are interesting findings.

Original languageEnglish
Pages (from-to)760-764
Number of pages5
JournalAmerican Journal of Hematology
Volume85
Issue number10
DOIs
Publication statusPublished - 2010 Jan 1

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Republic of Korea
Marginal Zone B-Cell Lymphoma
Natural Killer T-Cells
Neoplasms
Hodgkin Disease
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Lymphocytes
Peripheral T-Cell Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Sex Factors
Lymphoma, Large B-Cell, Diffuse
T-Cell Lymphoma
Age Factors
Incidence
Korea
Multiple Myeloma
Nose
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Yoon, SunOch ; Suh, Cheolwon ; Lee, Dae Ho ; Chi, Hyun Sook ; Park, Chan Jeoung ; Jang, Seong Soo ; Shin, Hai Rim ; Park, Bong Hee ; Huh, Jooryung. / Distribution of lymphoid neoplasms in the Republic of Korea : Analysis of 5318 cases according to the World Health Organization classification. In: American Journal of Hematology. 2010 ; Vol. 85, No. 10. pp. 760-764.
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Distribution of lymphoid neoplasms in the Republic of Korea : Analysis of 5318 cases according to the World Health Organization classification. / Yoon, SunOch; Suh, Cheolwon; Lee, Dae Ho; Chi, Hyun Sook; Park, Chan Jeoung; Jang, Seong Soo; Shin, Hai Rim; Park, Bong Hee; Huh, Jooryung.

In: American Journal of Hematology, Vol. 85, No. 10, 01.01.2010, p. 760-764.

Research output: Contribution to journalArticle

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