Diversity-oriented decoration of pyrrolo[1,2-a]pyrazines

Sujin Park, Youngeun Jung, Ikyon Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Diversity-oriented synthesis of a chemical library based on a pyrrolo[1,2-a]pyrazine core is described by using palladium-catalyzed direct C6 arylation of pyrrolo[1,2-a]pyrazines with various aryl bromides. The starting materials, pyrrolo[1,2-a]pyrazines, were easily synthesized by the base-mediated N-alkylation of pyrrole-2-carboxaldehyde with several 2-bromoacetophenones followed by dehydrative cyclization with incorporation of nitrogen by the action of ammonium acetate. Introduction of other functional groups on this chemical scaffold is also discussed herein.

Original languageEnglish
Pages (from-to)7534-7550
Number of pages17
JournalTetrahedron
Volume70
Issue number41
DOIs
Publication statusPublished - 2014 Oct 14

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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