Diversity-oriented functionalization of indolizines at the C3 position via multicomponent Kabachnik-Fields reaction

Jinwoo Kim; Yunkyung Heo; Youngeun Jung; Jinu Lee; Ikyon Kim

doi:10.1016/j.tet.2017.08.017

Diversity-oriented functionalization of indolizines at the C3 position via multicomponent Kabachnik-Fields reaction

Jinwoo Kim, Yunkyung Heo, Youngeun Jung, Jinu Lee, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

A diversity-oriented approach to new indolizines highly functionalized at the C3 position was achieved by using the Kabachnik-Fields three-component reaction. Some of the synthesized compounds exhibited a significant gap junction inhibitory activity.

Original language	English
Pages (from-to)	5759-5768
Number of pages	10
Journal	Tetrahedron
Volume	73
Issue number	39
DOIs	https://doi.org/10.1016/j.tet.2017.08.017
Publication status	Published - 2017

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) ( 2014R1A2A1A11050491 ) (to I. K.) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2016R1D1A1A02937397 ) (to J. L.). Appendix A

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Diversity-oriented functionalization of indolizines at the C3 position via multicomponent Kabachnik-Fields reaction",

abstract = "A diversity-oriented approach to new indolizines highly functionalized at the C3 position was achieved by using the Kabachnik-Fields three-component reaction. Some of the synthesized compounds exhibited a significant gap junction inhibitory activity.",

author = "Jinwoo Kim and Yunkyung Heo and Youngeun Jung and Jinu Lee and Ikyon Kim",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) ( 2014R1A2A1A11050491 ) (to I. K.) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2016R1D1A1A02937397 ) (to J. L.). Appendix A ",

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volume = "73",

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AU - Kim, Jinwoo

AU - Heo, Yunkyung

AU - Jung, Youngeun

AU - Lee, Jinu

AU - Kim, Ikyon

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) ( 2014R1A2A1A11050491 ) (to I. K.) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2016R1D1A1A02937397 ) (to J. L.). Appendix A

PY - 2017

Y1 - 2017

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AB - A diversity-oriented approach to new indolizines highly functionalized at the C3 position was achieved by using the Kabachnik-Fields three-component reaction. Some of the synthesized compounds exhibited a significant gap junction inhibitory activity.

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