A diversity-oriented approach to new indolizines highly functionalized at the C3 position was achieved by using the Kabachnik-Fields three-component reaction. Some of the synthesized compounds exhibited a significant gap junction inhibitory activity.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) ( 2014R1A2A1A11050491 ) (to I. K.) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2016R1D1A1A02937397 ) (to J. L.). Appendix A
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All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry