DNA bending at adenine · thymine tracts

Hyeon Sook Koo, Hen Ming Wu, Donald M. Crothers

Research output: Contribution to journalArticle

852 Citations (Scopus)

Abstract

Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalNature
Volume320
Issue number6062
DOIs
Publication statusPublished - 1986 Dec 1

All Science Journal Classification (ASJC) codes

  • General

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    Koo, H. S., Wu, H. M., & Crothers, D. M. (1986). DNA bending at adenine · thymine tracts. Nature, 320(6062), 501-506. https://doi.org/10.1038/320501a0