DNA bending at adenine · thymine tracts

Hyeon-Sook Koo, Hen Ming Wu, Donald M. Crothers

Research output: Contribution to journalArticle

852 Citations (Scopus)

Abstract

Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalNature
Volume320
Issue number6062
DOIs
Publication statusPublished - 1986 Dec 1

Fingerprint

Thymine
Adenine
Base Pairing
DNA
Direction compound

All Science Journal Classification (ASJC) codes

  • General

Cite this

Koo, H-S., Wu, H. M., & Crothers, D. M. (1986). DNA bending at adenine · thymine tracts. Nature, 320(6062), 501-506. https://doi.org/10.1038/320501a0
Koo, Hyeon-Sook ; Wu, Hen Ming ; Crothers, Donald M. / DNA bending at adenine · thymine tracts. In: Nature. 1986 ; Vol. 320, No. 6062. pp. 501-506.
@article{80fb1f4b7a0d480bb08e6a444d76e785,
title = "DNA bending at adenine · thymine tracts",
abstract = "Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.",
author = "Hyeon-Sook Koo and Wu, {Hen Ming} and Crothers, {Donald M.}",
year = "1986",
month = "12",
day = "1",
doi = "10.1038/320501a0",
language = "English",
volume = "320",
pages = "501--506",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6062",

}

Koo, H-S, Wu, HM & Crothers, DM 1986, 'DNA bending at adenine · thymine tracts', Nature, vol. 320, no. 6062, pp. 501-506. https://doi.org/10.1038/320501a0

DNA bending at adenine · thymine tracts. / Koo, Hyeon-Sook; Wu, Hen Ming; Crothers, Donald M.

In: Nature, Vol. 320, No. 6062, 01.12.1986, p. 501-506.

Research output: Contribution to journalArticle

TY - JOUR

T1 - DNA bending at adenine · thymine tracts

AU - Koo, Hyeon-Sook

AU - Wu, Hen Ming

AU - Crothers, Donald M.

PY - 1986/12/1

Y1 - 1986/12/1

N2 - Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

AB - Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

UR - http://www.scopus.com/inward/record.url?scp=0022477409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022477409&partnerID=8YFLogxK

U2 - 10.1038/320501a0

DO - 10.1038/320501a0

M3 - Article

VL - 320

SP - 501

EP - 506

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6062

ER -