DNA bending at adenine · thymine tracts

Hyeon Sook Koo; Hen Ming Wu; Donald M. Crothers

doi:10.1038/320501a0

DNA bending at adenine · thymine tracts

Hyeon Sook Koo, Hen Ming Wu, Donald M. Crothers

Department of Biochemistry

Research output: Contribution to journal › Article › peer-review

883 Citations (Scopus)

Abstract

Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

Original language	English
Pages (from-to)	501-506
Number of pages	6
Journal	Nature
Volume	320
Issue number	6062
DOIs	https://doi.org/10.1038/320501a0
Publication status	Published - 1986

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10.1038/320501a0

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title = "DNA bending at adenine · thymine tracts",

abstract = "Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.",

author = "Koo, {Hyeon Sook} and Wu, {Hen Ming} and Crothers, {Donald M.}",

year = "1986",

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AU - Koo, Hyeon Sook

AU - Wu, Hen Ming

AU - Crothers, Donald M.

PY - 1986

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N2 - Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

AB - Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

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DNA bending at adenine · thymine tracts

Abstract

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