DNA core@Inorganic shell

Dae Hwan Park, Jung Eun Kim, Jae Min Oh, Yong-Gun Shul, Jin Ho Choy

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A chemically well-defined Bio Core@Inorganic Shell nanohybrid, which consists of rationally designed DNA molecule core with a size of ∼100 nm and spherical inorganic nanoshell with an overall thickness of ∼10 nm reassembled with exfoliated layered metal hydroxide (MH nanosheets), is prepared. The DNA encapsulation and its release, due to the pH-dependent solubility of the MH nanoshell, plays a crucial role in maximizing the stability of base sequence-manipulated and probe-functionalized DNA molecules with designed information. The present DNA Core@MH Shell nanohybrid can provide wide bioinspired applications converged with nanotechnology, such as an advanced gene delivery system and a biomedical diagnostics, tracing/collection/sensing system for DNA-based information.

Original languageEnglish
Pages (from-to)16735-16736
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number47
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Nanoshells
DNA
Gene Transfer Techniques
Nanotechnology
DNA Probes
Molecules
Solubility
Nanosheets
Encapsulation
Metals
Genes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Park, D. H., Kim, J. E., Oh, J. M., Shul, Y-G., & Choy, J. H. (2010). DNA core@Inorganic shell. Journal of the American Chemical Society, 132(47), 16735-16736. https://doi.org/10.1021/ja105809e
Park, Dae Hwan ; Kim, Jung Eun ; Oh, Jae Min ; Shul, Yong-Gun ; Choy, Jin Ho. / DNA core@Inorganic shell. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 47. pp. 16735-16736.
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Park, DH, Kim, JE, Oh, JM, Shul, Y-G & Choy, JH 2010, 'DNA core@Inorganic shell', Journal of the American Chemical Society, vol. 132, no. 47, pp. 16735-16736. https://doi.org/10.1021/ja105809e

DNA core@Inorganic shell. / Park, Dae Hwan; Kim, Jung Eun; Oh, Jae Min; Shul, Yong-Gun; Choy, Jin Ho.

In: Journal of the American Chemical Society, Vol. 132, No. 47, 01.12.2010, p. 16735-16736.

Research output: Contribution to journalArticle

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AU - Park, Dae Hwan

AU - Kim, Jung Eun

AU - Oh, Jae Min

AU - Shul, Yong-Gun

AU - Choy, Jin Ho

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