We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.
Bibliographical noteFunding Information:
The results are based on data generated by TCGA Research Network ( http://cancergenome.nih.gov/ ). Supported in part by a cancer center grant from the National Cancer Institute ( P30CA072720 ) and generous support from the Marion and Norman Tanzman Charitable Foundation and Mr Malcolm Wernik.
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