DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

Joon Chae Na; Naoya Nagaya; Koon Ho Rha; Woong Kyu Han; Isaac Yi Kim

doi:10.1016/j.clgc.2019.05.004

DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

Joon Chae Na, Naoya Nagaya, Koon Ho Rha, Woong Kyu Han, Isaac Yi Kim

Department of Urology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

Original language	English
Pages (from-to)	299-305.e1
Journal	Clinical Genitourinary Cancer
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.clgc.2019.05.004
Publication status	Published - 2019 Aug

Bibliographical note

Funding Information:
The results are based on data generated by TCGA Research Network ( http://cancergenome.nih.gov/ ). Supported in part by a cancer center grant from the National Cancer Institute ( P30CA072720 ) and generous support from the Marion and Norman Tanzman Charitable Foundation and Mr Malcolm Wernik.

Publisher Copyright:
© 2019 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Oncology
Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clgc.2019.05.004

Cite this

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title = "DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome",

abstract = "We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.",

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AU - Han, Woong Kyu

AU - Kim, Isaac Yi

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AB - We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

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DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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