DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

Joon Chae Na, Naoya Nagaya, KoonHo Rha, WoongKyu Han, Isaac Yi Kim

Research output: Contribution to journalArticle

Abstract

We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

Original languageEnglish
Pages (from-to)299-305.e1
JournalClinical Genitourinary Cancer
Volume17
Issue number4
DOIs
Publication statusPublished - 2019 Aug 1

Fingerprint

Renal Cell Carcinoma
DNA Damage
Atlases
Kidney Neoplasms
Genome
Databases
Recurrence
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology

Cite this

@article{e9240b413c1d46aa9a355d996ab71424,
title = "DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome",
abstract = "We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.",
author = "Na, {Joon Chae} and Naoya Nagaya and KoonHo Rha and WoongKyu Han and Kim, {Isaac Yi}",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.clgc.2019.05.004",
language = "English",
volume = "17",
pages = "299--305.e1",
journal = "Clinical Genitourinary Cancer",
issn = "1558-7673",
publisher = "Elsevier",
number = "4",

}

DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome. / Na, Joon Chae; Nagaya, Naoya; Rha, KoonHo; Han, WoongKyu; Kim, Isaac Yi.

In: Clinical Genitourinary Cancer, Vol. 17, No. 4, 01.08.2019, p. 299-305.e1.

Research output: Contribution to journalArticle

TY - JOUR

T1 - DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

AU - Na, Joon Chae

AU - Nagaya, Naoya

AU - Rha, KoonHo

AU - Han, WoongKyu

AU - Kim, Isaac Yi

PY - 2019/8/1

Y1 - 2019/8/1

N2 - We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

AB - We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

UR - http://www.scopus.com/inward/record.url?scp=85067181883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067181883&partnerID=8YFLogxK

U2 - 10.1016/j.clgc.2019.05.004

DO - 10.1016/j.clgc.2019.05.004

M3 - Article

VL - 17

SP - 299-305.e1

JO - Clinical Genitourinary Cancer

JF - Clinical Genitourinary Cancer

SN - 1558-7673

IS - 4

ER -