DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

Joon Chae Na, Naoya Nagaya, Koon Ho Rha, Woong Kyu Han, Isaac Yi Kim

Research output: Contribution to journalArticle

Abstract

We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

Original languageEnglish
Pages (from-to)299-305.e1
JournalClinical Genitourinary Cancer
Volume17
Issue number4
DOIs
Publication statusPublished - 2019 Aug

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology

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