DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

Joon Chae Na, Naoya Nagaya, Koon Ho Rha, Woong Kyu Han, Isaac Yi Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

Original languageEnglish
Pages (from-to)299-305.e1
JournalClinical Genitourinary Cancer
Volume17
Issue number4
DOIs
Publication statusPublished - 2019 Aug

Bibliographical note

Funding Information:
The results are based on data generated by TCGA Research Network ( http://cancergenome.nih.gov/ ). Supported in part by a cancer center grant from the National Cancer Institute ( P30CA072720 ) and generous support from the Marion and Norman Tanzman Charitable Foundation and Mr Malcolm Wernik.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology

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