DNA repair Ku proteins in gastric cancer cells and pancreatic acinar cells

Research output: Contribution to journalShort survey

19 Citations (Scopus)

Abstract

The DNA repair protein Ku acts as a heterodimer of Ku70 and Ku80 that binds to the DNA ends, nicks, or single-to-double-strand transition. It has a crucial role for DNA double-strand-break repair. Either Ku70 or Ku80 itself may have a unique function that is independent of the other Ku subunit. In this review, the role of Ku on cell proliferation and apoptosis will be discussed. Ku acts as a regulator of transcription by interacting with the recombination signal binding protein Jκ and the NF-κB p50 homodimer to up-regulate p50 expression, which may regulate the proliferation of gastric cancer cells. Both Ku70 and Ku80 expressions are mediated by constitutively activated NF-κB and constitutively expressed cyclooxygenase-2 in gastric cancer cells, which may be related to gastric cell proliferation and carcinogenesis. In addition, nuclear loss of Ku may underlie the mechanism of apoptosis in pancreatic acinar cells after oxidative stress.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalAmino Acids
Volume34
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

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Acinar Cells
Immunoglobulin J Recombination Signal Sequence-Binding Protein
DNA Repair
Stomach Neoplasms
Repair
Cells
Cell Proliferation
Cell proliferation
Apoptosis
Single-Stranded DNA Breaks
Double-Stranded DNA Breaks
DNA
Cyclooxygenase 2
Stomach
Carcinogenesis
Proteins
Oxidative Stress
Oxidative stress
Up-Regulation
Transcription

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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DNA repair Ku proteins in gastric cancer cells and pancreatic acinar cells. / Kim, H.

In: Amino Acids, Vol. 34, No. 2, 01.02.2008, p. 195-202.

Research output: Contribution to journalShort survey

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