Abstract
The DNA repair protein Ku acts as a heterodimer of Ku70 and Ku80 that binds to the DNA ends, nicks, or single-to-double-strand transition. It has a crucial role for DNA double-strand-break repair. Either Ku70 or Ku80 itself may have a unique function that is independent of the other Ku subunit. In this review, the role of Ku on cell proliferation and apoptosis will be discussed. Ku acts as a regulator of transcription by interacting with the recombination signal binding protein Jκ and the NF-κB p50 homodimer to up-regulate p50 expression, which may regulate the proliferation of gastric cancer cells. Both Ku70 and Ku80 expressions are mediated by constitutively activated NF-κB and constitutively expressed cyclooxygenase-2 in gastric cancer cells, which may be related to gastric cell proliferation and carcinogenesis. In addition, nuclear loss of Ku may underlie the mechanism of apoptosis in pancreatic acinar cells after oxidative stress.
| Original language | English |
|---|---|
| Pages (from-to) | 195-202 |
| Number of pages | 8 |
| Journal | Amino Acids |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Clinical Biochemistry
- Organic Chemistry
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DNA repair Ku proteins in gastric cancer cells and pancreatic acinar cells. / Kim, H.
In: Amino Acids, Vol. 34, No. 2, 01.02.2008, p. 195-202.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - DNA repair Ku proteins in gastric cancer cells and pancreatic acinar cells
AU - Kim, H.
PY - 2008/2/1
Y1 - 2008/2/1
N2 - The DNA repair protein Ku acts as a heterodimer of Ku70 and Ku80 that binds to the DNA ends, nicks, or single-to-double-strand transition. It has a crucial role for DNA double-strand-break repair. Either Ku70 or Ku80 itself may have a unique function that is independent of the other Ku subunit. In this review, the role of Ku on cell proliferation and apoptosis will be discussed. Ku acts as a regulator of transcription by interacting with the recombination signal binding protein Jκ and the NF-κB p50 homodimer to up-regulate p50 expression, which may regulate the proliferation of gastric cancer cells. Both Ku70 and Ku80 expressions are mediated by constitutively activated NF-κB and constitutively expressed cyclooxygenase-2 in gastric cancer cells, which may be related to gastric cell proliferation and carcinogenesis. In addition, nuclear loss of Ku may underlie the mechanism of apoptosis in pancreatic acinar cells after oxidative stress.
AB - The DNA repair protein Ku acts as a heterodimer of Ku70 and Ku80 that binds to the DNA ends, nicks, or single-to-double-strand transition. It has a crucial role for DNA double-strand-break repair. Either Ku70 or Ku80 itself may have a unique function that is independent of the other Ku subunit. In this review, the role of Ku on cell proliferation and apoptosis will be discussed. Ku acts as a regulator of transcription by interacting with the recombination signal binding protein Jκ and the NF-κB p50 homodimer to up-regulate p50 expression, which may regulate the proliferation of gastric cancer cells. Both Ku70 and Ku80 expressions are mediated by constitutively activated NF-κB and constitutively expressed cyclooxygenase-2 in gastric cancer cells, which may be related to gastric cell proliferation and carcinogenesis. In addition, nuclear loss of Ku may underlie the mechanism of apoptosis in pancreatic acinar cells after oxidative stress.
UR - http://www.scopus.com/inward/record.url?scp=39049113800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049113800&partnerID=8YFLogxK
U2 - 10.1007/s00726-006-0411-1
DO - 10.1007/s00726-006-0411-1
M3 - Short survey
C2 - 17031478
AN - SCOPUS:39049113800
VL - 34
SP - 195
EP - 202
JO - Amino Acids
JF - Amino Acids
SN - 0939-4451
IS - 2
ER -