DNAsomes: Multifunctional DNA-based nanocarriers

Young Hoon Roh, Jong Bum Lee, Pichamon Kiatwuthinon, Mark R. Hartman, Judy J. Cha, Soong Ho Um, David A. Muller, Dan Luo

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Multifunctional DNAsomes: DNA-lipid amphiphiles self-assemble into novel "DNAsomes"a-liposome-like core-shell structures with subunits composed of branched DNA-lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA-RNA base-pairing, enabling efficient co-delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalSmall
Volume7
Issue number1
DOIs
Publication statusPublished - 2011 Jan 3

Fingerprint

RNA
Small Interfering RNA
DNA
Pharmaceutical Preparations
Lipids
Amphiphiles
Surface charge
Liposomes
Base Pairing
Nucleic Acids
Nucleic acids
Coloring Agents
Genes
Antibodies
Molecules
Dyes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Roh, Y. H., Lee, J. B., Kiatwuthinon, P., Hartman, M. R., Cha, J. J., Um, S. H., ... Luo, D. (2011). DNAsomes: Multifunctional DNA-based nanocarriers. Small, 7(1), 74-78. https://doi.org/10.1002/smll.201000752
Roh, Young Hoon ; Lee, Jong Bum ; Kiatwuthinon, Pichamon ; Hartman, Mark R. ; Cha, Judy J. ; Um, Soong Ho ; Muller, David A. ; Luo, Dan. / DNAsomes : Multifunctional DNA-based nanocarriers. In: Small. 2011 ; Vol. 7, No. 1. pp. 74-78.
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Roh, YH, Lee, JB, Kiatwuthinon, P, Hartman, MR, Cha, JJ, Um, SH, Muller, DA & Luo, D 2011, 'DNAsomes: Multifunctional DNA-based nanocarriers', Small, vol. 7, no. 1, pp. 74-78. https://doi.org/10.1002/smll.201000752

DNAsomes : Multifunctional DNA-based nanocarriers. / Roh, Young Hoon; Lee, Jong Bum; Kiatwuthinon, Pichamon; Hartman, Mark R.; Cha, Judy J.; Um, Soong Ho; Muller, David A.; Luo, Dan.

In: Small, Vol. 7, No. 1, 03.01.2011, p. 74-78.

Research output: Contribution to journalArticle

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Roh YH, Lee JB, Kiatwuthinon P, Hartman MR, Cha JJ, Um SH et al. DNAsomes: Multifunctional DNA-based nanocarriers. Small. 2011 Jan 3;7(1):74-78. https://doi.org/10.1002/smll.201000752