Abstract
This study was designed to evaluate the survival outcomes of patients undergoing simple cholecystectomy and to investigate which patients would benefit from cholecystectomy alone in treating gallbladder carcinoma. The available medical records of patients who underwent cholecystectomy alone for gallbladder carcinomas from August 1992 to February 2005 were retrospectively reviewed. Cancer stages were evaluated by clinical meaning based on the AJCC Cancer Staging Manual, 6th edition. "Clinical" R0, defined as gallbladder confined tumor (pT1-3 with negative resection margin) with cN0 and cM0, was tentatively established to evaluate the quality of simple cholecystectomy. Seventy-five patients underwent cholecystectomy alone for gallbladder carcinomas. Twenty-eight patients were male, and forty-seven patients were female, with their mean age 63.5 years (range, 29-80 years). Forty-one patients (54.7%) underwent laparoscopic cholecystectomy, and thirty-four patients (45.3%) underwent open cholecystectomy. T3 lesions were most common (26 patients), followed by T1 (24 patients), T2 (19 patients), and T4 (6 patients). "Clinical R0" could be defined in 48 patients (63%) after simple cholecystectomy. Multivariate analysis showed that incidental gallbladder carcinoma, T stage, and clinical R0 status were independent prognostic factors of long-term survival. When comparing survival outcomes of clinical R0 according to the T stage, no patients with Tis, T1a, and T1b had cancer-related mortality during follow-up. Especially, in patients with T2 gallbladder carcinomas, the mean survival rate was 68.9 months, and the 5-year survival rate was 77.8%. On the contrary, those with T3 lesions had poor prognoses. Cholecystectomy alone could be proper management for well-selected patients with gallbladder carcinomas (incidental gallbladder carcinoma, gallbladder confined carcinoma, clinical R0). More experiences and a proper prospective study must be performed to confirm the meaning of clinical R0 in treating gallbladder carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 1309-1316 |
| Number of pages | 8 |
| Journal | Journal of Gastrointestinal Surgery |
| Volume | 11 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2007 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Gastroenterology
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Does "clinical" R0 have validity in the choice of simple cholecystectomy for gallbladder carcinoma? / Kang, ChangMoo; Lee, Woo Jung; Choi, Gi Hong; Kim, Jun Young; Kim, Kyung Sik; Choi, Jin Sub; Kim, Byong Ro.
In: Journal of Gastrointestinal Surgery, Vol. 11, No. 10, 01.10.2007, p. 1309-1316.Research output: Contribution to journal › Article
TY - JOUR
T1 - Does "clinical" R0 have validity in the choice of simple cholecystectomy for gallbladder carcinoma?
AU - Kang, ChangMoo
AU - Lee, Woo Jung
AU - Choi, Gi Hong
AU - Kim, Jun Young
AU - Kim, Kyung Sik
AU - Choi, Jin Sub
AU - Kim, Byong Ro
PY - 2007/10/1
Y1 - 2007/10/1
N2 - This study was designed to evaluate the survival outcomes of patients undergoing simple cholecystectomy and to investigate which patients would benefit from cholecystectomy alone in treating gallbladder carcinoma. The available medical records of patients who underwent cholecystectomy alone for gallbladder carcinomas from August 1992 to February 2005 were retrospectively reviewed. Cancer stages were evaluated by clinical meaning based on the AJCC Cancer Staging Manual, 6th edition. "Clinical" R0, defined as gallbladder confined tumor (pT1-3 with negative resection margin) with cN0 and cM0, was tentatively established to evaluate the quality of simple cholecystectomy. Seventy-five patients underwent cholecystectomy alone for gallbladder carcinomas. Twenty-eight patients were male, and forty-seven patients were female, with their mean age 63.5 years (range, 29-80 years). Forty-one patients (54.7%) underwent laparoscopic cholecystectomy, and thirty-four patients (45.3%) underwent open cholecystectomy. T3 lesions were most common (26 patients), followed by T1 (24 patients), T2 (19 patients), and T4 (6 patients). "Clinical R0" could be defined in 48 patients (63%) after simple cholecystectomy. Multivariate analysis showed that incidental gallbladder carcinoma, T stage, and clinical R0 status were independent prognostic factors of long-term survival. When comparing survival outcomes of clinical R0 according to the T stage, no patients with Tis, T1a, and T1b had cancer-related mortality during follow-up. Especially, in patients with T2 gallbladder carcinomas, the mean survival rate was 68.9 months, and the 5-year survival rate was 77.8%. On the contrary, those with T3 lesions had poor prognoses. Cholecystectomy alone could be proper management for well-selected patients with gallbladder carcinomas (incidental gallbladder carcinoma, gallbladder confined carcinoma, clinical R0). More experiences and a proper prospective study must be performed to confirm the meaning of clinical R0 in treating gallbladder carcinoma.
AB - This study was designed to evaluate the survival outcomes of patients undergoing simple cholecystectomy and to investigate which patients would benefit from cholecystectomy alone in treating gallbladder carcinoma. The available medical records of patients who underwent cholecystectomy alone for gallbladder carcinomas from August 1992 to February 2005 were retrospectively reviewed. Cancer stages were evaluated by clinical meaning based on the AJCC Cancer Staging Manual, 6th edition. "Clinical" R0, defined as gallbladder confined tumor (pT1-3 with negative resection margin) with cN0 and cM0, was tentatively established to evaluate the quality of simple cholecystectomy. Seventy-five patients underwent cholecystectomy alone for gallbladder carcinomas. Twenty-eight patients were male, and forty-seven patients were female, with their mean age 63.5 years (range, 29-80 years). Forty-one patients (54.7%) underwent laparoscopic cholecystectomy, and thirty-four patients (45.3%) underwent open cholecystectomy. T3 lesions were most common (26 patients), followed by T1 (24 patients), T2 (19 patients), and T4 (6 patients). "Clinical R0" could be defined in 48 patients (63%) after simple cholecystectomy. Multivariate analysis showed that incidental gallbladder carcinoma, T stage, and clinical R0 status were independent prognostic factors of long-term survival. When comparing survival outcomes of clinical R0 according to the T stage, no patients with Tis, T1a, and T1b had cancer-related mortality during follow-up. Especially, in patients with T2 gallbladder carcinomas, the mean survival rate was 68.9 months, and the 5-year survival rate was 77.8%. On the contrary, those with T3 lesions had poor prognoses. Cholecystectomy alone could be proper management for well-selected patients with gallbladder carcinomas (incidental gallbladder carcinoma, gallbladder confined carcinoma, clinical R0). More experiences and a proper prospective study must be performed to confirm the meaning of clinical R0 in treating gallbladder carcinoma.
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U2 - 10.1007/s11605-007-0225-9
DO - 10.1007/s11605-007-0225-9
M3 - Article
VL - 11
SP - 1309
EP - 1316
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
SN - 1091-255X
IS - 10
ER -