Domestic arthropods and their allergens

Yong Jeong Kyoung, Chein Soo Hong, Tai Soon Yong

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Allergy prevalence has increased worldwide over the last 25 years along with industrialization and westernized lifestyles. Indoor allergens are primarily responsible for the sensitization and development of atopic diseases. The main indoor allergens are known to be derived from various arthropods which account for up to 80% of the kingdom Animalia. The two classes of arthropods are Insecta, which includes cockroaches, flies, mosquitoes, ants and silverfishes, and Arachnida, which includes mites, spiders, ticks, and scorpions and are the main sources of the allergens. Excreted materials, cast-overs from skin-molting, and dead debris are sources of allergens that can sensitize genetically predisposed individuals and elicit allergic disorders. The use of molecular biology techniques has contributed to the identification and characterization of an ever-increasing number of allergens. However, key determinants and allergen properties that drive allergic responses are poorly understood. The biological characterization of allergens will provide an understanding of the pathogenesis of allergic diseases and contribute to the development of new diagnostic and therapeutic approaches.

Original languageEnglish
Pages (from-to)934-942
Number of pages9
JournalProtein and Peptide Letters
Volume14
Issue number10
DOIs
Publication statusPublished - 2007 Oct

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry

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