Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units

Myungock Kim, Youngeun Jung, Ikyon Kim

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A highly efficient [4 + 2] annulation route to polysubstituted indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as a key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes in good to excellent yields, leading to indolizines with various substituents at the 5, 6, and 7 positions depending on the reacting active methylene partners.

Original languageEnglish
Pages (from-to)10395-10404
Number of pages10
JournalJournal of Organic Chemistry
Volume78
Issue number20
DOIs
Publication statusPublished - 2013 Oct 18

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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