Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units

Myungock Kim, Youngeun Jung, Ikyon Kim

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A highly efficient [4 + 2] annulation route to polysubstituted indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as a key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes in good to excellent yields, leading to indolizines with various substituents at the 5, 6, and 7 positions depending on the reacting active methylene partners.

Original languageEnglish
Pages (from-to)10395-10404
Number of pages10
JournalJournal of Organic Chemistry
Volume78
Issue number20
DOIs
Publication statusPublished - 2013 Oct 18

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Indolizines
Cyclization
Condensation
3-hydroxybutanal
pyridine

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units. / Kim, Myungock; Jung, Youngeun; Kim, Ikyon.

In: Journal of Organic Chemistry, Vol. 78, No. 20, 18.10.2013, p. 10395-10404.

Research output: Contribution to journalArticle

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