Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease

Kyoungwon Baik, Jungho Cha, Jee Hyun Ham, Gwang Min Baek, Mun Kyung Sunwoo, Jin Yong Hong, Na Young Shin, Jae Seung Kim, Jong Min Lee, Seung Koo Lee, Young Ho Sohn, philhyu Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine-dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP-CIT positron emission tomography imaging and resting-state functional connectivity in 23 drug naïve de novo patients with PD to elucidate dopamine-dependent functional networks. The major finding is that the patterns of dopamine-dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine-dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine-dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine-dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine-dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian-related motor and cognitive performance. Hum Brain Mapp 35:5431-5441, 2014.

Original languageEnglish
Pages (from-to)5431-5441
Number of pages11
JournalHuman Brain Mapping
Volume35
Issue number11
DOIs
Publication statusPublished - 2014 Nov 1

Fingerprint

Parkinson Disease
Dopamine
Putamen
Corpus Striatum
Secondary Parkinson Disease
Pathology
Dopaminergic Neurons
Gyrus Cinguli
Denervation
Substantia Nigra
Positron-Emission Tomography
Seeds
Brain
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Baik, Kyoungwon ; Cha, Jungho ; Ham, Jee Hyun ; Baek, Gwang Min ; Sunwoo, Mun Kyung ; Hong, Jin Yong ; Shin, Na Young ; Kim, Jae Seung ; Lee, Jong Min ; Lee, Seung Koo ; Sohn, Young Ho ; Lee, philhyu. / Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease. In: Human Brain Mapping. 2014 ; Vol. 35, No. 11. pp. 5431-5441.
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abstract = "Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine-dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP-CIT positron emission tomography imaging and resting-state functional connectivity in 23 drug na{\"i}ve de novo patients with PD to elucidate dopamine-dependent functional networks. The major finding is that the patterns of dopamine-dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine-dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine-dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine-dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine-dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian-related motor and cognitive performance. Hum Brain Mapp 35:5431-5441, 2014.",
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Baik, K, Cha, J, Ham, JH, Baek, GM, Sunwoo, MK, Hong, JY, Shin, NY, Kim, JS, Lee, JM, Lee, SK, Sohn, YH & Lee, P 2014, 'Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease', Human Brain Mapping, vol. 35, no. 11, pp. 5431-5441. https://doi.org/10.1002/hbm.22561

Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease. / Baik, Kyoungwon; Cha, Jungho; Ham, Jee Hyun; Baek, Gwang Min; Sunwoo, Mun Kyung; Hong, Jin Yong; Shin, Na Young; Kim, Jae Seung; Lee, Jong Min; Lee, Seung Koo; Sohn, Young Ho; Lee, philhyu.

In: Human Brain Mapping, Vol. 35, No. 11, 01.11.2014, p. 5431-5441.

Research output: Contribution to journalArticle

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T1 - Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease

AU - Baik, Kyoungwon

AU - Cha, Jungho

AU - Ham, Jee Hyun

AU - Baek, Gwang Min

AU - Sunwoo, Mun Kyung

AU - Hong, Jin Yong

AU - Shin, Na Young

AU - Kim, Jae Seung

AU - Lee, Jong Min

AU - Lee, Seung Koo

AU - Sohn, Young Ho

AU - Lee, philhyu

PY - 2014/11/1

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N2 - Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine-dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP-CIT positron emission tomography imaging and resting-state functional connectivity in 23 drug naïve de novo patients with PD to elucidate dopamine-dependent functional networks. The major finding is that the patterns of dopamine-dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine-dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine-dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine-dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine-dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian-related motor and cognitive performance. Hum Brain Mapp 35:5431-5441, 2014.

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