Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[ 18 F]Mefway

Minkyung Lee, Young Hoon Ryu, Won Gil Cho, Tae Joo Jeon, Chulhyoung Lyoo, Yeo Wool Kang, Soo Jin Lee, Chul Hoon Kim, Dong Goo Kim, Jee Hae Kang, Young Beom Seo, Chi Hoon Yi, Kyochul Lee, Tae Hyun Choi, Jae Yong Choi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[ 18 F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BP ND ) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[ 18 F]Mefway BP ND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalApplied Radiation and Isotopes
Volume94
DOIs
Publication statusPublished - 2014 Jan 1

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serotonin
hippocampus
neurons
destruction
rats
cerebellum
causes

All Science Journal Classification (ASJC) codes

  • Radiation

Cite this

Lee, Minkyung ; Ryu, Young Hoon ; Cho, Won Gil ; Jeon, Tae Joo ; Lyoo, Chulhyoung ; Kang, Yeo Wool ; Lee, Soo Jin ; Kim, Chul Hoon ; Kim, Dong Goo ; Kang, Jee Hae ; Seo, Young Beom ; Yi, Chi Hoon ; Lee, Kyochul ; Choi, Tae Hyun ; Choi, Jae Yong. / Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[ 18 F]Mefway In: Applied Radiation and Isotopes. 2014 ; Vol. 94. pp. 30-34.
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abstract = "The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[ 18 F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BP ND ) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[ 18 F]Mefway BP ND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.",
author = "Minkyung Lee and Ryu, {Young Hoon} and Cho, {Won Gil} and Jeon, {Tae Joo} and Chulhyoung Lyoo and Kang, {Yeo Wool} and Lee, {Soo Jin} and Kim, {Chul Hoon} and Kim, {Dong Goo} and Kang, {Jee Hae} and Seo, {Young Beom} and Yi, {Chi Hoon} and Kyochul Lee and Choi, {Tae Hyun} and Choi, {Jae Yong}",
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Lee, M, Ryu, YH, Cho, WG, Jeon, TJ, Lyoo, C, Kang, YW, Lee, SJ, Kim, CH, Kim, DG, Kang, JH, Seo, YB, Yi, CH, Lee, K, Choi, TH & Choi, JY 2014, ' Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[ 18 F]Mefway ', Applied Radiation and Isotopes, vol. 94, pp. 30-34. https://doi.org/10.1016/j.apradiso.2014.06.016

Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[ 18 F]Mefway . / Lee, Minkyung; Ryu, Young Hoon; Cho, Won Gil; Jeon, Tae Joo; Lyoo, Chulhyoung; Kang, Yeo Wool; Lee, Soo Jin; Kim, Chul Hoon; Kim, Dong Goo; Kang, Jee Hae; Seo, Young Beom; Yi, Chi Hoon; Lee, Kyochul; Choi, Tae Hyun; Choi, Jae Yong.

In: Applied Radiation and Isotopes, Vol. 94, 01.01.2014, p. 30-34.

Research output: Contribution to journalArticle

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T1 - Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[ 18 F]Mefway

AU - Lee, Minkyung

AU - Ryu, Young Hoon

AU - Cho, Won Gil

AU - Jeon, Tae Joo

AU - Lyoo, Chulhyoung

AU - Kang, Yeo Wool

AU - Lee, Soo Jin

AU - Kim, Chul Hoon

AU - Kim, Dong Goo

AU - Kang, Jee Hae

AU - Seo, Young Beom

AU - Yi, Chi Hoon

AU - Lee, Kyochul

AU - Choi, Tae Hyun

AU - Choi, Jae Yong

PY - 2014/1/1

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N2 - The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[ 18 F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BP ND ) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[ 18 F]Mefway BP ND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.

AB - The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[ 18 F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BP ND ) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[ 18 F]Mefway BP ND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.

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