Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[18F]Mefway

Minkyung Lee, Young Hoon Ryu, Won Gil Cho, Tae Joo Jeon, Chul Hyoung Lyoo, Yeo Wool Kang, Soo Jin Lee, Chul Hoon Kim, Dong Goo Kim, Jee Hae Kang, Young Beom Seo, Chi Hoon Yi, Kyochul Lee, Tae Hyun Choi, Jae Yong Choi

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Abstract

The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[18F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BPND) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[18F]Mefway BPND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalApplied Radiation and Isotopes
Volume94
DOIs
Publication statusPublished - 2014 Dec

All Science Journal Classification (ASJC) codes

  • Radiation

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    Lee, M., Ryu, Y. H., Cho, W. G., Jeon, T. J., Lyoo, C. H., Kang, Y. W., Lee, S. J., Kim, C. H., Kim, D. G., Kang, J. H., Seo, Y. B., Yi, C. H., Lee, K., Choi, T. H., & Choi, J. Y. (2014). Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[18F]Mefway. Applied Radiation and Isotopes, 94, 30-34. https://doi.org/10.1016/j.apradiso.2014.06.016