Dose-response association between smoking cessation and arterial stiffness: The cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort

Ga Bin Lee, Jee Seon Shim, Hyeon Chang Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background and Objectives: Cigarette smoking has been reported to be associated with arterial stiffness. However, the clinical relevance of smoking cessation on arterial stiffness is debatable. Thus, we evaluated whether smoking cessation is associated with arterial stiffness. Methods: A total of 1,169 male participants aged 30-64 years with absence of cardiovascular diseases in 2013-2017 were selected from the Cardiovascular and Metabolic Disease Etiology Research Center cohort study. The subjects were classified into the following 5 groups based on self-reporting: non-smokers, former smokers (<1, 1 to <10, and ≥10, years after cessation), and current smokers. Arterial stiffness was assessed using the augmentation index (AIx). The radial artery AIx was obtained from the peripheral artery waveform. The association was explored cross-sectionally. Results: The AIx of former smokers did not differ from that of non-smokers (p=0.089). However, after former smokers were stratified by duration of smoking cessation, we noted a linear trend according to the smoking status (p<0.001). Men who quit smoking <1 year ago showed an elevated AIx (β=3.94, standard error=1.54, p=0.011) as much as ones of current smokers (β=4.39, standard error=0.74, p<0.001), while those who quit more than a decade ago showed an AIx similar to that of non-smokers (β=0.35, standard error=0.82, p=0.670) after controlling covariates. Conclusions: A dose-response association between smoking cessation and AIx was revealed, which implies the possibility of a reversible effect of smoking cessation on arterial stiffness. Therefore, our findings may motivate current smokers to modify their smoking habits to delay or reverse disease progression.

Original languageEnglish
Pages (from-to)361-369
Number of pages9
JournalKorean Circulation Journal
Issue number4
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This work supported by a grant from the Korea Health Technology R&D Project funded by the Ministry of Health and Welfare, Republic of Korea (grant number HI13C0715).

Publisher Copyright:
Copyright © 2020. The Korean Society of Cardiology

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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