Double-effector nanoparticles: A synergistic approach to apoptotic hyperthermia

Dongwon Yoo, Heeyeong Jeong, Christian Preihs, Jin Sil Choi, Tae Hyun Shin, Jonathan L. Sessler, Jinwoo Cheon

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Highly efficient apoptotic hyperthermia is achieved using a double-effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm3) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.

Original languageEnglish
Pages (from-to)12482-12485
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number50
DOIs
Publication statusPublished - 2012 Dec 7

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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