Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells

Young Han Lee, He Jin Lee, Seung Jae Lee, Do Sik Min, Suk Hwan Baek, Yong Sik Kim, Sung Ho Ryu, Pann Ghill Suh

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Abstract

Phospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-γ1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-γ2 were not altered. Northern blot analysis showed that the levels of PLC-γ1 and -γ2 transcripts were not changed. These results suggest that the expression of PLC-γ1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalFEBS Letters
Volume358
Issue number2
DOIs
Publication statusPublished - 1995 Jan 23

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Lee, Y. H., Lee, H. J., Lee, S. J., Min, D. S., Baek, S. H., Kim, Y. S., Ryu, S. H., & Suh, P. G. (1995). Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells. FEBS Letters, 358(2), 105-108. https://doi.org/10.1016/0014-5793(94)01404-O