Down-regulation of serum high- mobility group box 1 protein in patients with pulmonary tuberculosis and nontuberculous mycobacterial lung disease

Su Young Kim, Won Jung Koh, Hye Yun Park, Kyeongman Jeon, Soo Youn Lee, Jae Joon Yim, Sung Jae Shin

Research output: Contribution to journalArticle

Abstract

Background: Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous mycobacterial (NTM) lung disease, and compared it to mycobacterial lung disease. Methods: A total of 60 patients newly diagnosed with NTM lung disease, 44 culture-positive pulmonary tuberculosis (TB) patients, and 34 healthy controls, were included in this study. The serum HMGB1 concentrations were quantified using HMGB1 enzyme-linked immunosorbent assay kits. Results: Serum HMGB1 level in patients with pulmonary TB or NTM lung disease, was significantly lower than that of the healthy controls. In addition, the serum HMGB1 level in TB patients was significantly lower than patients with NTM lung disease. However, the levels in NTM patient subgroups did not differ according to the causative species, disease progression, and disease phenotype. Conclusion: Although low levels of serum HMGB1 has the potential to be a marker of mycobacterial lung disease, these levels were unable to differentiate disease progression and disease phenotype in NTM lung diseases.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalTuberculosis and Respiratory Diseases
Volume80
Issue number2
DOIs
Publication statusPublished - 2017 Apr

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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