Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Hyunsoo Chung, Hanbyoul Cho, Candice Perry, Jaekyung Song, Kris Ylaya, Heejeong Lee, Jae-Hoon Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p<0.001). Low ERp57 expression was significantly associated with worse overall survival (HR=12.19, p=0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
JournalBiomarkers
Volume18
Issue number7
DOIs
Publication statusPublished - 2013 Nov 1

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Uterine Cervical Neoplasms
Down-Regulation
Messenger RNA
Tissue
Cervical Intraepithelial Neoplasia
Neoplasms
Proteins
Immunohistochemistry
Survival

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Chung, Hyunsoo ; Cho, Hanbyoul ; Perry, Candice ; Song, Jaekyung ; Ylaya, Kris ; Lee, Heejeong ; Kim, Jae-Hoon. / Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer. In: Biomarkers. 2013 ; Vol. 18, No. 7. pp. 573-579.
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Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer. / Chung, Hyunsoo; Cho, Hanbyoul; Perry, Candice; Song, Jaekyung; Ylaya, Kris; Lee, Heejeong; Kim, Jae-Hoon.

In: Biomarkers, Vol. 18, No. 7, 01.11.2013, p. 573-579.

Research output: Contribution to journalArticle

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T1 - Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

AU - Chung, Hyunsoo

AU - Cho, Hanbyoul

AU - Perry, Candice

AU - Song, Jaekyung

AU - Ylaya, Kris

AU - Lee, Heejeong

AU - Kim, Jae-Hoon

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AB - Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p<0.001). Low ERp57 expression was significantly associated with worse overall survival (HR=12.19, p=0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

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