Abstract
Sticky stuff: A versatile strategy to spatially control gene expressions of mammalian cells is developed. A catecholamine polymer (PEI-C) is used to functionalize surfaces of adeno-associated viruses (AAV). Because of the underwater adhesive property of catechol, AAV/PEI-C hybrid vectors become highly "sticky", resulting in spatially patterned viral attachment onto substrates by the simple "gene-vector drawing" technique (see picture).
| Original language | English |
|---|---|
| Pages (from-to) | 5598-5601 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2012 Jun 4 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
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Cite this
Kim, E., Song, I. T., Lee, S., Kim, J. S., Lee, H., & Jang, J. H. (2012). Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression. Angewandte Chemie - International Edition, 51(23), 5598-5601. https://doi.org/10.1002/anie.201201495