Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression

Eunmi Kim; In Taek Song; Slgirim Lee; Jung Suk Kim; Haeshin Lee; Jae Hyung Jang

doi:10.1002/anie.201201495

Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression

Eunmi Kim, In Taek Song, Slgirim Lee, Jung Suk Kim, Haeshin Lee, Jae Hyung Jang

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Sticky stuff: A versatile strategy to spatially control gene expressions of mammalian cells is developed. A catecholamine polymer (PEI-C) is used to functionalize surfaces of adeno-associated viruses (AAV). Because of the underwater adhesive property of catechol, AAV/PEI-C hybrid vectors become highly "sticky", resulting in spatially patterned viral attachment onto substrates by the simple "gene-vector drawing" technique (see picture).

Original language	English
Pages (from-to)	5598-5601
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	23
DOIs	https://doi.org/10.1002/anie.201201495
Publication status	Published - 2012 Jun 4

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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AU - Lee, Haeshin

AU - Jang, Jae Hyung

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Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression

Abstract

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