Abstract
Sticky stuff: A versatile strategy to spatially control gene expressions of mammalian cells is developed. A catecholamine polymer (PEI-C) is used to functionalize surfaces of adeno-associated viruses (AAV). Because of the underwater adhesive property of catechol, AAV/PEI-C hybrid vectors become highly "sticky", resulting in spatially patterned viral attachment onto substrates by the simple "gene-vector drawing" technique (see picture).
Original language | English |
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Pages (from-to) | 5598-5601 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 23 |
DOIs | |
Publication status | Published - 2012 Jun 4 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)