Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression

Eunmi Kim, In Taek Song, Slgirim Lee, Jung Suk Kim, Haeshin Lee, Jae Hyung Jang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Sticky stuff: A versatile strategy to spatially control gene expressions of mammalian cells is developed. A catecholamine polymer (PEI-C) is used to functionalize surfaces of adeno-associated viruses (AAV). Because of the underwater adhesive property of catechol, AAV/PEI-C hybrid vectors become highly "sticky", resulting in spatially patterned viral attachment onto substrates by the simple "gene-vector drawing" technique (see picture).

Original languageEnglish
Pages (from-to)5598-5601
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number23
DOIs
Publication statusPublished - 2012 Jun 4

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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