Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression

Eunmi Kim, In Taek Song, Slgirim Lee, Jung Suk Kim, Haeshin Lee, Jae Hyung Jang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Sticky stuff: A versatile strategy to spatially control gene expressions of mammalian cells is developed. A catecholamine polymer (PEI-C) is used to functionalize surfaces of adeno-associated viruses (AAV). Because of the underwater adhesive property of catechol, AAV/PEI-C hybrid vectors become highly "sticky", resulting in spatially patterned viral attachment onto substrates by the simple "gene-vector drawing" technique (see picture).

Original languageEnglish
Pages (from-to)5598-5601
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number23
DOIs
Publication statusPublished - 2012 Jun 4

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Polyetherimides
Viruses
Gene expression
Catecholamines
Adhesives
Polymers
Genes
Cells
Substrates
catechol

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Kim, Eunmi ; Song, In Taek ; Lee, Slgirim ; Kim, Jung Suk ; Lee, Haeshin ; Jang, Jae Hyung. / Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 23. pp. 5598-5601.
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Drawing sticky adeno-associated viruses on surfaces for spatially patterned gene expression. / Kim, Eunmi; Song, In Taek; Lee, Slgirim; Kim, Jung Suk; Lee, Haeshin; Jang, Jae Hyung.

In: Angewandte Chemie - International Edition, Vol. 51, No. 23, 04.06.2012, p. 5598-5601.

Research output: Contribution to journalArticle

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