Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway

Hyeyon Kim, Haein Kim, Jae Young Kwon, Jeong Taeg Seo, DongMin Shin, Seok Jun Moon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Animals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich nutrients that contribute to various cellular functions. Recent evidence suggests FAs are detected through the gustatory system to promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required for FA detection but other signaling molecules are unknown. Here, we show Gr64e is required for the behavioral and electrophysiological responses to FAs. GR64e and TRPA1 are interchangeable when they act downstream of PLC: TRPA1 can substitute for GR64e in FA but not glycerol sensing, and GR64e can substitute for TRPA1 in aristolochic acid but not N-methylmaleimide sensing. In contrast to its role in FA sensing, GR64e functions as a ligand-gated ion channel for glycerol detection. Our results identify a novel FA transduction molecule and reveal that Drosophila Grs can act via distinct molecular mechanisms depending on context.

Original languageEnglish
Article numbere1007229
JournalPLoS Genetics
Volume14
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1

Fingerprint

phospholipase C
Type C Phospholipases
Drosophila
Fatty Acids
fatty acid
fatty acids
Glycerol
glycerol
Ligand-Gated Ion Channels
Food
nutrients
ion channels
nutrient
Nonesterified Fatty Acids
free fatty acids
ligand
acids
energy
ion
animal

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

Cite this

Kim, Hyeyon ; Kim, Haein ; Kwon, Jae Young ; Seo, Jeong Taeg ; Shin, DongMin ; Moon, Seok Jun. / Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway. In: PLoS Genetics. 2018 ; Vol. 14, No. 2.
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Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway. / Kim, Hyeyon; Kim, Haein; Kwon, Jae Young; Seo, Jeong Taeg; Shin, DongMin; Moon, Seok Jun.

In: PLoS Genetics, Vol. 14, No. 2, e1007229, 01.02.2018.

Research output: Contribution to journalArticle

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AU - Kim, Haein

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