Drosophila immunity: Genes on the third chromosome required for the response to bacterial infection

Louisa P. Wu, Kwang Min Choe, Yiran Lu, Kathryn V. Anderson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We have screened the third chromosome of Drosophila melanogaster for mutations that prevent the normal immune response. We identified mutant lines on the basis of their failure to induce transcription of an antibacterial peptide gene in response to infection or their failure to form melanized clots at the site of wounding. These mutations define 14 genes [immune response deficient (ird) genes] that have distinct roles in the immune response. We have identified the molecular basis of several ird phenotypes. Two genes, scribble and kurtz/modulo, affect the cellular organization of the fat body, the tissue responsible for antimicrobial peptide production. Two ird genes encode components of the signaling pathways that mediate responses to bacterial infection, a Drosophila gene encoding a homolog of IκB kinase (DmIkkβ) and Relish, a Rel-family transcription factor. These genetic studies should provide a basis for a comprehensive understanding of the genetic control of immune responses in Drosophila.

Original languageEnglish
Pages (from-to)189-199
Number of pages11
JournalGenetics
Volume159
Issue number1
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Genetics

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