Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Kyoung Ran Kim, Da Rae Kim, Taemin Lee, Ji Young Yhee, Byeong-Su Kim, Ick Chan Kwon, Dae Ro Ahn

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

Original languageEnglish
Pages (from-to)2010-2012
Number of pages3
JournalChemical Communications
Volume49
Issue number20
DOIs
Publication statusPublished - 2013 Mar 11

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Drug delivery
DNA
Cells
Doxorubicin
Pharmaceutical Preparations
Drug Carriers
Biocompatible Materials
Biomaterials

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Kim, Kyoung Ran ; Kim, Da Rae ; Lee, Taemin ; Yhee, Ji Young ; Kim, Byeong-Su ; Kwon, Ick Chan ; Ahn, Dae Ro. / Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells. In: Chemical Communications. 2013 ; Vol. 49, No. 20. pp. 2010-2012.
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Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells. / Kim, Kyoung Ran; Kim, Da Rae; Lee, Taemin; Yhee, Ji Young; Kim, Byeong-Su; Kwon, Ick Chan; Ahn, Dae Ro.

In: Chemical Communications, Vol. 49, No. 20, 11.03.2013, p. 2010-2012.

Research output: Contribution to journalArticle

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