Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer

Sun Mi Lee, Hyung Joon Kim, Sook Young Kim, Min Kyung Kwon, Sol Kim, Arthur Cho, Mijin Yun, Jeon Soo Shin, Kyung Hwa Yoo

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

To investigate the possibility of treating multidrug-resistant tumors with targeted chemo-photothermal treatment, we conducted invitro and invivo studies using a doxorubicin (DOX)-resistant DLD-1 cell line (DLD-1/DOX) and nude mice with human xenograft tumors, respectively. The chemo-photothermal treatment consisted of DOX-loaded-poly(lactic co-glycolic acid)-Au half-shell nanoparticles with targeting moieties of anti-death receptor-4 monoclonal antibody conjugated to the Au surface. The cells or xenografted tumors treated with nanoparticles were exposed to near infrared light for 10min, which caused an increase in temperature to 45°C. Chemo-photothermal treatment resulted in a large reduction in the rate of tumor xenograft growth on DLD-1/DOX tumor-bearing mice with a much smaller dose of DOX than conventional DOX chemotherapy. These results demonstrate that targeted chemo-photothermal treatment can provide high therapeutic efficacy and low toxicity in the treatment of multidrug-resistant tumors.

Original languageEnglish
Pages (from-to)2272-2282
Number of pages11
JournalBiomaterials
Volume35
Issue number7
DOIs
Publication statusPublished - 2014 Feb

Bibliographical note

Funding Information:
This work was financially supported by MEST through the National Research Foundation (NRF) of Korea ( NRF-2012R1A4A1029061 , NRF-2011-0017611 , and NRF-2013R1A1A304009309 ), Brain Korea 21 Plus Project for Medical Sciences , Brain Korea 21 Plus Project for Physics , and MHW through the Korean Health Technology R&D Project (Grant No. A110905 )

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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