Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis

Hyung Joon Kim, Sun Mi Lee, Kyu Hyung Park, Chin Hee Mun, Yong Beom Park, Kyung Hwa Yoo

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

We have developed methotrexate (MTX)-loaded poly(lactic-co-glycolic acid, PLGA) gold (Au)/iron (Fe)/gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD), which can be applied for magnetic targeted chemo-photothermal treatment, and in vivo multimodal imaging of rheumatoid arthritis (RA). Upon near-infrared (NIR) irradiation, local heat is generated at the inflammation region due to the NIR resonance of Au half-shells and MTX release from PLGA nanoparticles is accelerated. The Fe half-shell layer embedded between the Au half-shell layers enables in vivo T2-magnetic resonance (MR) imaging in addition to NIR absorbance imaging. Furthermore, the delivery of the nanoparticles to the inflammation region in collagen-induced arthritic (CIA) mice, and their retention can be enhanced under external magnetic field. When combined with consecutive NIR irradiation and external magnetic field application, these nanoparticles provide enhanced therapeutic effects with an MTX dosages of only 0.05% dosage compared to free MTX therapy for the treatment of RA.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalBiomaterials
Volume61
DOIs
Publication statusPublished - 2015 Aug 1

Bibliographical note

Funding Information:
This research was financially supported by a grant from the Korean Health Technology R&D Project, Ministry of Health &Welfare (Grant No. A110905 ) and Ministry of Science, KT and Future Planning through the National Research Foundation (NRF) of Korea (Nos. 2011-0017486 , 2012R1A4A1029061 , and 2013R1A1A3A04009309 ).

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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