Drug resistance patterns of multidrug- and extensively drug-resistant tuberculosis in Korea

Amplification of resistance to oral second-line drugs

Chang Ki Kim, So Youn Shin, Hee Jin Kim, Kyungwon Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We aimed to analyze the drug resistance patterns of multidrug-resistant and extensively drug-resistant tuberculosis (TB) and the difference of drug resistance among various settings for health care in Korea. The data of drug susceptibility testing in 2009 was analyzed in order to secure sufficient number of patients from various settings in Korea. Patients were categorized by types of institutions into four groups, which comprised new and previously treated patients from public health care centers (PHC), the private sector, and Double-barred Cross clinics (DBC). The resistance rates to first-line drugs were uniformly high in every group. While the resistance rates to second-line drugs were not as high as first-line drugs, there was a pattern that drug resistance rates were lowest for PHC and highest for DBC. The differences of the resistance rates were more prominent for oral second-line drugs. Our findings implied that drug resistance to oral second-line drugs was significantly amplified during multidrug-resistant-TB treatment in Korea. Therefore, an individualized approach is recommended for treating drug-resistant-TB based on susceptibility testing results to prevent acquisition or amplification of drug resistance.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalAnnals of laboratory medicine
Volume37
Issue number4
DOIs
Publication statusPublished - 2017 Jul 1

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Extensively Drug-Resistant Tuberculosis
Korea
Drug Resistance
Amplification
Pharmaceutical Preparations
Multidrug-Resistant Tuberculosis
Delivery of Health Care
Public Health
Health care
Private Sector
Public health
Testing

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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abstract = "We aimed to analyze the drug resistance patterns of multidrug-resistant and extensively drug-resistant tuberculosis (TB) and the difference of drug resistance among various settings for health care in Korea. The data of drug susceptibility testing in 2009 was analyzed in order to secure sufficient number of patients from various settings in Korea. Patients were categorized by types of institutions into four groups, which comprised new and previously treated patients from public health care centers (PHC), the private sector, and Double-barred Cross clinics (DBC). The resistance rates to first-line drugs were uniformly high in every group. While the resistance rates to second-line drugs were not as high as first-line drugs, there was a pattern that drug resistance rates were lowest for PHC and highest for DBC. The differences of the resistance rates were more prominent for oral second-line drugs. Our findings implied that drug resistance to oral second-line drugs was significantly amplified during multidrug-resistant-TB treatment in Korea. Therefore, an individualized approach is recommended for treating drug-resistant-TB based on susceptibility testing results to prevent acquisition or amplification of drug resistance.",
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Drug resistance patterns of multidrug- and extensively drug-resistant tuberculosis in Korea : Amplification of resistance to oral second-line drugs. / Kim, Chang Ki; Shin, So Youn; Kim, Hee Jin; Lee, Kyungwon.

In: Annals of laboratory medicine, Vol. 37, No. 4, 01.07.2017, p. 323-326.

Research output: Contribution to journalArticle

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