dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia

Jina Park, Jeongmi Lee, Jaewon Shim, Woongsu Han, Jinu Lee, Yong Chul Bae, Yun Doo Chung, Chul Hoon Kim, Seok Jun Moon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mechanically gated ion channels convert sound into an electrical signal for the sense of hearing. In Drosophila melanogaster, several transient receptor potential (TRP) channels have been implicated to be involved in this process. TRPN (NompC) and TRPV (Inactive) channels are localized in the distal and proximal ciliary zones of auditory receptor neurons, respectively. This segregated ciliary localization suggests distinct roles in auditory transduction. However, the regulation of this localization is not fully understood. Here we show that the Drosophila Tubby homolog, King tubby (hereafter called dTULP) regulates ciliary localization of TRPs. dTULP-deficient flies show uncoordinated movement and complete loss of sound-evoked action potentials. Inactive and NompC are mislocalized in the cilia of auditory receptor neurons in the dTulp mutants, indicating that dTULP is required for proper cilia membrane protein localization. This is the first demonstration that dTULP regulates TRP channel localization in cilia, and suggests that dTULP is a protein that regulates ciliary neurosensory functions.

Original languageEnglish
Article numbere1003814
JournalPLoS Genetics
Volume9
Issue number9
DOIs
Publication statusPublished - 2013 Sep 1

Fingerprint

Transient Receptor Potential Channels
Cilia
cilia
Drosophila melanogaster
neurons
Neurons
receptors
ion channels
hearing
action potentials
Ion Channels
Evoked Potentials
Diptera
membrane proteins
Hearing
Action Potentials
Drosophila
protein
Membrane Proteins
mutants

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Park, Jina ; Lee, Jeongmi ; Shim, Jaewon ; Han, Woongsu ; Lee, Jinu ; Bae, Yong Chul ; Chung, Yun Doo ; Kim, Chul Hoon ; Moon, Seok Jun. / dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia. In: PLoS Genetics. 2013 ; Vol. 9, No. 9.
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dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia. / Park, Jina; Lee, Jeongmi; Shim, Jaewon; Han, Woongsu; Lee, Jinu; Bae, Yong Chul; Chung, Yun Doo; Kim, Chul Hoon; Moon, Seok Jun.

In: PLoS Genetics, Vol. 9, No. 9, e1003814, 01.09.2013.

Research output: Contribution to journalArticle

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