Dual-phase CT collateral score: A predictor of clinical outcome in patients with acute ischemic stroke

Na Young Shin, Kyung Eun Kim, Mina Park, Young Dae Kim, Dong Joon Kim, Sung Jun Ahn, Ji Hoe Heo, Seung Koo Lee

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13 Citations (Scopus)

Abstract

Background and Purpose: The presence of good collaterals on CT angiography (CTA) is a well-known predictor for favorable outcome in acute ischemic stroke. Recently, multiphase CT has been introduced as a more accurate method in assessing collaterals. The aim of this study was to assess the ability of dual-phase CT to evaluate collateral status and predict clinical outcome. Methods: Forty-three patients who underwent both dual-phase CT and transfemoral cerebral angiography (TFCA) for occluded intracranial internal carotid artery (ICA) and/or middle cerebral artery (M1 segment) were recruited from a prospectively collected database. The collateral status on dual-phase CT was graded by using a 4-point scale: grade 0 = no collaterals; 1 = some collaterals with persistence of some defects; 2 = slow but complete collaterals; and 3 = fast and complete collaterals. Univariate and multivariate analysis were performed to define the independent predictors for favorable outcome at 3 months. Results: Dual-phase CT collateral status (p = 0.744) showed higher correlation with TFCA collateral status than CTA collateral status (p = 0.596) and substantial interobserver agreement (weighted k = 0.776). In the univariate analysis, age, history of hypertension, collateral scores on CTA, dual-phase CT, and TFCA, occlusion in intracranial ICA, final infarct volume, and symptomatic hemorrhage were significantly associated with outcome. Among them, only the dual-phase CT collateral score was an independent predictor for favorable outcome (OR = 26.342 (2.788-248.864); P = 0.004) in the multivariate analysis. Conclusions: The collateral status on dual-phase CT can be a useful predictor for clinical outcome in acute stroke patients, especially when advanced CT techniques are not available in emergent situations.

Original languageEnglish
Article numbere107379
JournalPloS one
Volume9
Issue number9
DOIs
Publication statusPublished - 2014 Sep

Bibliographical note

Publisher Copyright:
© 2014 Shin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

  • General

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