Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion

Dol Mi Kim, Chul Woo Ahn, Kyung Rae Kim, Won Hong Soon, Suk Nam Moon, Soo Cha Bong, Sungkil Lim, Chul Lee Hyun, Eunjig Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Context: Extrapancreatic somatostatinoma is very rare and clinically distinguished from its pancreatic counterpart because somatostatinoma syndrome with mild diabetes is rare in extrapancreatic somatostatinoma because of poor secretion of somatostatin. Moreover, because somatostatin inhibits the secretion of insulin and glucagon simultaneously, true diabetic ketoacidosis (DKA) seldom ensues. Patient: A 23-yr-old woman presented with DKA and an abdominal mass. A computed tomography scan showed a huge, encapsulated mass in a duodenal submucous portion. A high circulating level of somatostatin was detected (67.2 pmol/liter; reference range, 0.6-7.3 pmol/liter). Intervention: The tumor mass was successfully removed with Whipple's procedure, and the patient gradually recovered both clinically and biochemically. Results: Immunohistochemical staining of the tumor tissue exhibited diffusely positive for somatostatin and somatostatin-28 but negative for insulin, glucagon, calcitonin, serotonin, and S-100. Conclusion: As far as we know, this is the first case report of gastrointestinal somatostatinoma associated with DKA.

Original languageEnglish
Pages (from-to)6310-6315
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number11
DOIs
Publication statusPublished - 2005 Nov 1

Fingerprint

Somatostatinoma
Somatostatin-28
Diabetic Ketoacidosis
Somatostatin
Glucagon
Tumors
Insulin
Calcitonin
Medical problems
Tomography
Neoplasms
Serotonin
Reference Values
Tissue
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kim, Dol Mi ; Ahn, Chul Woo ; Kim, Kyung Rae ; Soon, Won Hong ; Moon, Suk Nam ; Bong, Soo Cha ; Lim, Sungkil ; Hyun, Chul Lee ; Lee, Eunjig. / Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 11. pp. 6310-6315.
@article{4009d9f0f49b4f51bd7d12e7e1658944,
title = "Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion",
abstract = "Context: Extrapancreatic somatostatinoma is very rare and clinically distinguished from its pancreatic counterpart because somatostatinoma syndrome with mild diabetes is rare in extrapancreatic somatostatinoma because of poor secretion of somatostatin. Moreover, because somatostatin inhibits the secretion of insulin and glucagon simultaneously, true diabetic ketoacidosis (DKA) seldom ensues. Patient: A 23-yr-old woman presented with DKA and an abdominal mass. A computed tomography scan showed a huge, encapsulated mass in a duodenal submucous portion. A high circulating level of somatostatin was detected (67.2 pmol/liter; reference range, 0.6-7.3 pmol/liter). Intervention: The tumor mass was successfully removed with Whipple's procedure, and the patient gradually recovered both clinically and biochemically. Results: Immunohistochemical staining of the tumor tissue exhibited diffusely positive for somatostatin and somatostatin-28 but negative for insulin, glucagon, calcitonin, serotonin, and S-100. Conclusion: As far as we know, this is the first case report of gastrointestinal somatostatinoma associated with DKA.",
author = "Kim, {Dol Mi} and Ahn, {Chul Woo} and Kim, {Kyung Rae} and Soon, {Won Hong} and Moon, {Suk Nam} and Bong, {Soo Cha} and Sungkil Lim and Hyun, {Chul Lee} and Eunjig Lee",
year = "2005",
month = "11",
day = "1",
doi = "10.1210/jc.2004-1904",
language = "English",
volume = "90",
pages = "6310--6315",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "11",

}

Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion. / Kim, Dol Mi; Ahn, Chul Woo; Kim, Kyung Rae; Soon, Won Hong; Moon, Suk Nam; Bong, Soo Cha; Lim, Sungkil; Hyun, Chul Lee; Lee, Eunjig.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 11, 01.11.2005, p. 6310-6315.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion

AU - Kim, Dol Mi

AU - Ahn, Chul Woo

AU - Kim, Kyung Rae

AU - Soon, Won Hong

AU - Moon, Suk Nam

AU - Bong, Soo Cha

AU - Lim, Sungkil

AU - Hyun, Chul Lee

AU - Lee, Eunjig

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Context: Extrapancreatic somatostatinoma is very rare and clinically distinguished from its pancreatic counterpart because somatostatinoma syndrome with mild diabetes is rare in extrapancreatic somatostatinoma because of poor secretion of somatostatin. Moreover, because somatostatin inhibits the secretion of insulin and glucagon simultaneously, true diabetic ketoacidosis (DKA) seldom ensues. Patient: A 23-yr-old woman presented with DKA and an abdominal mass. A computed tomography scan showed a huge, encapsulated mass in a duodenal submucous portion. A high circulating level of somatostatin was detected (67.2 pmol/liter; reference range, 0.6-7.3 pmol/liter). Intervention: The tumor mass was successfully removed with Whipple's procedure, and the patient gradually recovered both clinically and biochemically. Results: Immunohistochemical staining of the tumor tissue exhibited diffusely positive for somatostatin and somatostatin-28 but negative for insulin, glucagon, calcitonin, serotonin, and S-100. Conclusion: As far as we know, this is the first case report of gastrointestinal somatostatinoma associated with DKA.

AB - Context: Extrapancreatic somatostatinoma is very rare and clinically distinguished from its pancreatic counterpart because somatostatinoma syndrome with mild diabetes is rare in extrapancreatic somatostatinoma because of poor secretion of somatostatin. Moreover, because somatostatin inhibits the secretion of insulin and glucagon simultaneously, true diabetic ketoacidosis (DKA) seldom ensues. Patient: A 23-yr-old woman presented with DKA and an abdominal mass. A computed tomography scan showed a huge, encapsulated mass in a duodenal submucous portion. A high circulating level of somatostatin was detected (67.2 pmol/liter; reference range, 0.6-7.3 pmol/liter). Intervention: The tumor mass was successfully removed with Whipple's procedure, and the patient gradually recovered both clinically and biochemically. Results: Immunohistochemical staining of the tumor tissue exhibited diffusely positive for somatostatin and somatostatin-28 but negative for insulin, glucagon, calcitonin, serotonin, and S-100. Conclusion: As far as we know, this is the first case report of gastrointestinal somatostatinoma associated with DKA.

UR - http://www.scopus.com/inward/record.url?scp=27744442513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744442513&partnerID=8YFLogxK

U2 - 10.1210/jc.2004-1904

DO - 10.1210/jc.2004-1904

M3 - Article

VL - 90

SP - 6310

EP - 6315

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 11

ER -