Dynamics of alveolar bone healing after the removal of orthodontic temporary anchorage devices

Sung Jin Kim, Young Don Ha, Eunji Kim, Woowon Jang, Soonshin Hwang, Tung Nguyen, Ching Chang Ko, Yoon Jeong Choi, Kyungho Kim, Chooryung Judi Chung

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs). Methods: Miniscrews (N = 32) were inserted into the buccal inter-radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13-week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Serial changes in bone apposition at the removal and intact control sites were evaluated using μCT, histology, and bone histomorphometry. Results: Gradual bone apposition at the TAD removal site was noted with bone volume/tissue volume (BV/TV) reaching the level of the control alveolar bone by 7 weeks. Histologically, newly formed woven bone was detected within the removal site which was distinct from the surrounding pre-existing alveolar bone at 13 weeks. Accelerated mineral apposition rate (MAR) and bone formation rate (BFR) were noted between 2 and 6 weeks in the removal site (P < 0.05). Although MAR and BFR gradually decreased after its peak at 2-4 weeks, BFR in the removal site was still higher than the control site at 10-12 weeks (P < 0.05). Conclusions: Spontaneous bone healing was noted after TAD removal with regional acceleration of MAR and BFR within 2-6 weeks. However, the removal site was mainly filled with woven bone even after 13 weeks, suggesting a longer healing period is required for the quality of the alveolar bone to reach levels comparable to the surrounding alveolar bone.

Original languageEnglish
Pages (from-to)388-395
Number of pages8
JournalJournal of Periodontal Research
Volume54
Issue number4
DOIs
Publication statusPublished - 2019 Aug 1

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Orthodontics
Bone and Bones
Equipment and Supplies
Osteogenesis
Device Removal
Minerals
Cheek
Histology
Dogs

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Kim, Sung Jin ; Ha, Young Don ; Kim, Eunji ; Jang, Woowon ; Hwang, Soonshin ; Nguyen, Tung ; Ko, Ching Chang ; Choi, Yoon Jeong ; Kim, Kyungho ; Chung, Chooryung Judi. / Dynamics of alveolar bone healing after the removal of orthodontic temporary anchorage devices. In: Journal of Periodontal Research. 2019 ; Vol. 54, No. 4. pp. 388-395.
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abstract = "Objective: The aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs). Methods: Miniscrews (N = 32) were inserted into the buccal inter-radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13-week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Serial changes in bone apposition at the removal and intact control sites were evaluated using μCT, histology, and bone histomorphometry. Results: Gradual bone apposition at the TAD removal site was noted with bone volume/tissue volume (BV/TV) reaching the level of the control alveolar bone by 7 weeks. Histologically, newly formed woven bone was detected within the removal site which was distinct from the surrounding pre-existing alveolar bone at 13 weeks. Accelerated mineral apposition rate (MAR) and bone formation rate (BFR) were noted between 2 and 6 weeks in the removal site (P < 0.05). Although MAR and BFR gradually decreased after its peak at 2-4 weeks, BFR in the removal site was still higher than the control site at 10-12 weeks (P < 0.05). Conclusions: Spontaneous bone healing was noted after TAD removal with regional acceleration of MAR and BFR within 2-6 weeks. However, the removal site was mainly filled with woven bone even after 13 weeks, suggesting a longer healing period is required for the quality of the alveolar bone to reach levels comparable to the surrounding alveolar bone.",
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Dynamics of alveolar bone healing after the removal of orthodontic temporary anchorage devices. / Kim, Sung Jin; Ha, Young Don; Kim, Eunji; Jang, Woowon; Hwang, Soonshin; Nguyen, Tung; Ko, Ching Chang; Choi, Yoon Jeong; Kim, Kyungho; Chung, Chooryung Judi.

In: Journal of Periodontal Research, Vol. 54, No. 4, 01.08.2019, p. 388-395.

Research output: Contribution to journalArticle

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T1 - Dynamics of alveolar bone healing after the removal of orthodontic temporary anchorage devices

AU - Kim, Sung Jin

AU - Ha, Young Don

AU - Kim, Eunji

AU - Jang, Woowon

AU - Hwang, Soonshin

AU - Nguyen, Tung

AU - Ko, Ching Chang

AU - Choi, Yoon Jeong

AU - Kim, Kyungho

AU - Chung, Chooryung Judi

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N2 - Objective: The aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs). Methods: Miniscrews (N = 32) were inserted into the buccal inter-radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13-week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Serial changes in bone apposition at the removal and intact control sites were evaluated using μCT, histology, and bone histomorphometry. Results: Gradual bone apposition at the TAD removal site was noted with bone volume/tissue volume (BV/TV) reaching the level of the control alveolar bone by 7 weeks. Histologically, newly formed woven bone was detected within the removal site which was distinct from the surrounding pre-existing alveolar bone at 13 weeks. Accelerated mineral apposition rate (MAR) and bone formation rate (BFR) were noted between 2 and 6 weeks in the removal site (P < 0.05). Although MAR and BFR gradually decreased after its peak at 2-4 weeks, BFR in the removal site was still higher than the control site at 10-12 weeks (P < 0.05). Conclusions: Spontaneous bone healing was noted after TAD removal with regional acceleration of MAR and BFR within 2-6 weeks. However, the removal site was mainly filled with woven bone even after 13 weeks, suggesting a longer healing period is required for the quality of the alveolar bone to reach levels comparable to the surrounding alveolar bone.

AB - Objective: The aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs). Methods: Miniscrews (N = 32) were inserted into the buccal inter-radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13-week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Serial changes in bone apposition at the removal and intact control sites were evaluated using μCT, histology, and bone histomorphometry. Results: Gradual bone apposition at the TAD removal site was noted with bone volume/tissue volume (BV/TV) reaching the level of the control alveolar bone by 7 weeks. Histologically, newly formed woven bone was detected within the removal site which was distinct from the surrounding pre-existing alveolar bone at 13 weeks. Accelerated mineral apposition rate (MAR) and bone formation rate (BFR) were noted between 2 and 6 weeks in the removal site (P < 0.05). Although MAR and BFR gradually decreased after its peak at 2-4 weeks, BFR in the removal site was still higher than the control site at 10-12 weeks (P < 0.05). Conclusions: Spontaneous bone healing was noted after TAD removal with regional acceleration of MAR and BFR within 2-6 weeks. However, the removal site was mainly filled with woven bone even after 13 weeks, suggesting a longer healing period is required for the quality of the alveolar bone to reach levels comparable to the surrounding alveolar bone.

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