Dynamics of alveolar bone healing after the removal of orthodontic temporary anchorage devices

Sung Jin Kim, Young Don Ha, Eunji Kim, Woowon Jang, Soonshin Hwang, Tung Nguyen, Ching Chang Ko, Yoon Jeong Choi, Kyung Ho Kim, Chooryung J. Chung

Research output: Contribution to journalArticlepeer-review


Objective: The aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs). Methods: Miniscrews (N = 32) were inserted into the buccal inter-radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13-week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Serial changes in bone apposition at the removal and intact control sites were evaluated using μCT, histology, and bone histomorphometry. Results: Gradual bone apposition at the TAD removal site was noted with bone volume/tissue volume (BV/TV) reaching the level of the control alveolar bone by 7 weeks. Histologically, newly formed woven bone was detected within the removal site which was distinct from the surrounding pre-existing alveolar bone at 13 weeks. Accelerated mineral apposition rate (MAR) and bone formation rate (BFR) were noted between 2 and 6 weeks in the removal site (P < 0.05). Although MAR and BFR gradually decreased after its peak at 2-4 weeks, BFR in the removal site was still higher than the control site at 10-12 weeks (P < 0.05). Conclusions: Spontaneous bone healing was noted after TAD removal with regional acceleration of MAR and BFR within 2-6 weeks. However, the removal site was mainly filled with woven bone even after 13 weeks, suggesting a longer healing period is required for the quality of the alveolar bone to reach levels comparable to the surrounding alveolar bone.

Original languageEnglish
Pages (from-to)388-395
Number of pages8
JournalJournal of Periodontal Research
Issue number4
Publication statusPublished - 2019 Aug

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1A2B4014882) and Health Fellowship Foundation of Korea. We thank Ms. Tae Yeon Kim for her assistance throughout the study and Dr. Christian Piers for the English editing.

All Science Journal Classification (ASJC) codes

  • Periodontics

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