Dynamics of ARF regulation that control senescence and cancer

Aram Ko, Su Yeon Han, Jaewhan Song

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

ARF is an alternative reading frame product of the INK4a/ARF locus, inactivated in numerous human cancers. ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. It functions by sequestering MDM2 (a p53 E3 ligase) in the nucleolus, thus activating p53. Besides MDM2, ARF has numerous other interacting partners that induce either cellular senescence or apoptosis in a p53-independent manner. This further complicates the dynamics of the ARF network. Expression of ARF is frequently disrupted in human cancers, mainly due to epigenetic and transcriptional regulation. Vigorous studies on various transcription factors that either positively or negatively regulate ARF transcription have been carried out. However, recent focus on posttranslational modifications, particularly ubiquitination, indicates wider dynamic controls of ARF than previously known. In this review, we discuss the role and dynamic regulation of ARF in senescence and cancer.

Original languageEnglish
Pages (from-to)598-606
Number of pages9
JournalBMB Reports
Volume49
Issue number11
DOIs
Publication statusPublished - 2016 Jan 1

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Cell growth
Cell Aging
Neoplasms
Ubiquitin-Protein Ligases
Transcription
Reading Frames
Tumors
Ubiquitination
Transcription Factors
Post Translational Protein Processing
Growth
Epigenomics
Apoptosis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Ko, Aram ; Han, Su Yeon ; Song, Jaewhan. / Dynamics of ARF regulation that control senescence and cancer. In: BMB Reports. 2016 ; Vol. 49, No. 11. pp. 598-606.
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Dynamics of ARF regulation that control senescence and cancer. / Ko, Aram; Han, Su Yeon; Song, Jaewhan.

In: BMB Reports, Vol. 49, No. 11, 01.01.2016, p. 598-606.

Research output: Contribution to journalReview article

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