Dysfunctional pancreatic β-cells of critical stress play a more prominent role in the development of stress diabetes in critically burned Korean subjects

byungwan lee, Hur Jun, Hae Jun Yim, Jae Bong Park, Heungjeong Woo, Hyung Joon Yoo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purposes of this study are to identify the predictive parameters for the development of stress-induced hyperglycemia and to investigate the glucose metabolic homeostasis in critically burned Korean subjects. We conducted a prospective cross-sectional study of adult patients with glucose management targeting fasting and postprandial blood glucose levels less than 140 and 200 mg/dL, respectively, in patients with unrecognized diabetes. Clinical and laboratory stress parameters and insulin secretory and sensitivity parameters were assessed. Stimulated C-peptide and 24-hour urinary free cortisol predicted new-onset stress diabetes requiring insulin therapy. The subjects requiring insulin therapy were leaner and more insulin sensitive than insulin-free subjects, without significance. Glycated hemoglobin, stimulated C-peptide, homeostasis model assessment of insulin resistance, and age had a significant influence on the mean daily dose of insulin. Our present data showed that Korean subjects with dysfunctional pancreatic β-cells of critical stress are prone to become stress diabetic and require more insulin to control the hyperglycemia.

Original languageEnglish
Pages (from-to)1307-1315
Number of pages9
JournalMetabolism: Clinical and Experimental
Volume59
Issue number9
DOIs
Publication statusPublished - 2010 Sep 1

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Insulin
C-Peptide
Hyperglycemia
Insulin Resistance
Homeostasis
Hemoglobin C
Glucose
Glycosylated Hemoglobin A
Hydrocortisone
Blood Glucose
Fasting
Cross-Sectional Studies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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abstract = "The purposes of this study are to identify the predictive parameters for the development of stress-induced hyperglycemia and to investigate the glucose metabolic homeostasis in critically burned Korean subjects. We conducted a prospective cross-sectional study of adult patients with glucose management targeting fasting and postprandial blood glucose levels less than 140 and 200 mg/dL, respectively, in patients with unrecognized diabetes. Clinical and laboratory stress parameters and insulin secretory and sensitivity parameters were assessed. Stimulated C-peptide and 24-hour urinary free cortisol predicted new-onset stress diabetes requiring insulin therapy. The subjects requiring insulin therapy were leaner and more insulin sensitive than insulin-free subjects, without significance. Glycated hemoglobin, stimulated C-peptide, homeostasis model assessment of insulin resistance, and age had a significant influence on the mean daily dose of insulin. Our present data showed that Korean subjects with dysfunctional pancreatic β-cells of critical stress are prone to become stress diabetic and require more insulin to control the hyperglycemia.",
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Dysfunctional pancreatic β-cells of critical stress play a more prominent role in the development of stress diabetes in critically burned Korean subjects. / lee, byungwan; Jun, Hur; Yim, Hae Jun; Park, Jae Bong; Woo, Heungjeong; Yoo, Hyung Joon.

In: Metabolism: Clinical and Experimental, Vol. 59, No. 9, 01.09.2010, p. 1307-1315.

Research output: Contribution to journalArticle

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