Abstract
The purposes of this study are to identify the predictive parameters for the development of stress-induced hyperglycemia and to investigate the glucose metabolic homeostasis in critically burned Korean subjects. We conducted a prospective cross-sectional study of adult patients with glucose management targeting fasting and postprandial blood glucose levels less than 140 and 200 mg/dL, respectively, in patients with unrecognized diabetes. Clinical and laboratory stress parameters and insulin secretory and sensitivity parameters were assessed. Stimulated C-peptide and 24-hour urinary free cortisol predicted new-onset stress diabetes requiring insulin therapy. The subjects requiring insulin therapy were leaner and more insulin sensitive than insulin-free subjects, without significance. Glycated hemoglobin, stimulated C-peptide, homeostasis model assessment of insulin resistance, and age had a significant influence on the mean daily dose of insulin. Our present data showed that Korean subjects with dysfunctional pancreatic β-cells of critical stress are prone to become stress diabetic and require more insulin to control the hyperglycemia.
| Original language | English |
|---|---|
| Pages (from-to) | 1307-1315 |
| Number of pages | 9 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 59 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2010 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Dysfunctional pancreatic β-cells of critical stress play a more prominent role in the development of stress diabetes in critically burned Korean subjects. / lee, byungwan; Jun, Hur; Yim, Hae Jun; Park, Jae Bong; Woo, Heungjeong; Yoo, Hyung Joon.
In: Metabolism: Clinical and Experimental, Vol. 59, No. 9, 01.09.2010, p. 1307-1315.Research output: Contribution to journal › Article
TY - JOUR
T1 - Dysfunctional pancreatic β-cells of critical stress play a more prominent role in the development of stress diabetes in critically burned Korean subjects
AU - lee, byungwan
AU - Jun, Hur
AU - Yim, Hae Jun
AU - Park, Jae Bong
AU - Woo, Heungjeong
AU - Yoo, Hyung Joon
PY - 2010/9/1
Y1 - 2010/9/1
N2 - The purposes of this study are to identify the predictive parameters for the development of stress-induced hyperglycemia and to investigate the glucose metabolic homeostasis in critically burned Korean subjects. We conducted a prospective cross-sectional study of adult patients with glucose management targeting fasting and postprandial blood glucose levels less than 140 and 200 mg/dL, respectively, in patients with unrecognized diabetes. Clinical and laboratory stress parameters and insulin secretory and sensitivity parameters were assessed. Stimulated C-peptide and 24-hour urinary free cortisol predicted new-onset stress diabetes requiring insulin therapy. The subjects requiring insulin therapy were leaner and more insulin sensitive than insulin-free subjects, without significance. Glycated hemoglobin, stimulated C-peptide, homeostasis model assessment of insulin resistance, and age had a significant influence on the mean daily dose of insulin. Our present data showed that Korean subjects with dysfunctional pancreatic β-cells of critical stress are prone to become stress diabetic and require more insulin to control the hyperglycemia.
AB - The purposes of this study are to identify the predictive parameters for the development of stress-induced hyperglycemia and to investigate the glucose metabolic homeostasis in critically burned Korean subjects. We conducted a prospective cross-sectional study of adult patients with glucose management targeting fasting and postprandial blood glucose levels less than 140 and 200 mg/dL, respectively, in patients with unrecognized diabetes. Clinical and laboratory stress parameters and insulin secretory and sensitivity parameters were assessed. Stimulated C-peptide and 24-hour urinary free cortisol predicted new-onset stress diabetes requiring insulin therapy. The subjects requiring insulin therapy were leaner and more insulin sensitive than insulin-free subjects, without significance. Glycated hemoglobin, stimulated C-peptide, homeostasis model assessment of insulin resistance, and age had a significant influence on the mean daily dose of insulin. Our present data showed that Korean subjects with dysfunctional pancreatic β-cells of critical stress are prone to become stress diabetic and require more insulin to control the hyperglycemia.
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U2 - 10.1016/j.metabol.2009.11.022
DO - 10.1016/j.metabol.2009.11.022
M3 - Article
VL - 59
SP - 1307
EP - 1315
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 9
ER -