Early changes in 25-hydroxyvitamin D levels and bone markers after monthly risedronate with cholecalciferol in Korean patients with osteoporosis

Ho Yeon Chung, Jawon Koo, Su Kyoung Kwon, Moo IL Kang, Seong Hwan Moon, Jin Young Park, Chan Soo Shin, Byung Koo Yoon, Hyun Koo Yoon, Jae Suk Chang, Yoon Sok Chung, Hyoung Moo Park

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Abstract

Purpose: This study investigated the effcacy and safety of monthly risedronate, with and without cholecalciferol, on 25-hydroxyvitamin D (25[OH]D) levels and bone markers in Korean patients with osteoporosis.Methods: A randomized, double-blinded, prospective, 16-week clinical trial was conducted in ten hospitals. A total of 150 subjects with osteoporosis were randomized to one of the two treatment groups: RSDM+ (monthly risedronate 150 mg and cholecalciferol 30,000 IU combined in a single pill, n = 74) or RSDM (monthly risedronate 150 mg alone, n = 76). We measured serum levels of 25-hydroxyvitamin D (25[OH]D), parathyroid hormone (PTH), and bone markers, as well as performing muscle-function tests at baseline and after 16 weeks of treatment. Results: After 16 weeks, serum 25(OH)D levels significantly increased from 17.8 to 26.8 ng/mL in the RSDM+ group, but did not change in the RSDM group. The RSDM+ group exhibited signifcantly decreased serum PTH from 46 to 36.7 pg/mL, while the RSDM group showed a tendency for PTH to increase from 38 to 40.6 pg/mL. In both groups, serum bone-specifc alkaline phosphatase and C-terminal telopeptide rapidly declined, with signifcance at 16 weeks; there were no signifcant differences between the groups.Conclusion: A once-monthly pill of risedronate and cholecalciferol provided equivalent antiresorptive effcacy to risedronate alone in terms of bone turnover and improved 25(OH)D levels over the 16-week treatment period without signifcant adverse events in Korean patients with osteoporosis.

Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalClinical Interventions in Aging
Volume8
DOIs
Publication statusPublished - 2013 May 29

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All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Chung, H. Y., Koo, J., Kwon, S. K., Kang, M. IL., Moon, S. H., Park, J. Y., Shin, C. S., Yoon, B. K., Yoon, H. K., Chang, J. S., Chung, Y. S., & Park, H. M. (2013). Early changes in 25-hydroxyvitamin D levels and bone markers after monthly risedronate with cholecalciferol in Korean patients with osteoporosis. Clinical Interventions in Aging, 8, 597-603. https://doi.org/10.2147/CIA.S44395