Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study /692/53/2421 /692/699/75/230 /59 /59/57 /123 /128 article

Yoo Jin Hong, Heae Surng Park, Jeffrey Kihyun Park, Kyunghwa Han, Chul Hwan Park, Tai Kyung Kim, Sae Jong Yoo, Ji Yeon Lee, Pan Ki Kim, Jin Hur, Hye Jeong Lee, Young Jin Kim, Young Joo Suh, Mun Young Paek, Byoung Wook Choi

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Abstract

A reliable, non-invasive diagnostic method is needed for early detection and serial monitoring of cardiotoxicity, a well-known side effect of chemotherapy. This study aimed to assess the feasibility of T1-mapping cardiac magnetic resonance imaging (CMR) for evaluating subclinical myocardial changes in a doxorubicin-induced cardiotoxicity rabbit model. Adult male New Zealand White rabbits were injected twice-weekly with doxorubicin and subjected to CMR on a clinical 3T MR system before and every 2-4 weeks post-drug administration. Native T1 and extracellular volume (ECV) values were measured at six mid-left ventricle (LV) and specific LV lesions. Histological assessments evaluated myocardial injury and fibrosis. Three pre-model and 11 post-model animals were included. Myocardial injury was observed from 3 weeks. Mean LV myocardium ECV values increased significantly from week 3 before LV ejection fraction decreases (week 6), and ECVs of the RV upper/lower insertion sites and papillary muscle exceeded those of the LV. The mean native T1 value in the mid-LV increased significantly increased from week 6, and LV myocardium ECV correlated strongly with the degree of fibrosis (r = 0.979, p < 0.001). Myocardial T1 mapping, particularly ECV values, reliably and non-invasively detected early cardiotoxicity, allowing serial monitoring of chemotherapy-induced cardiotoxicity.

Original languageEnglish
Article number2663
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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Hong, Y. J., Park, H. S., Park, J. K., Han, K., Park, C. H., Kim, T. K., Yoo, S. J., Lee, J. Y., Kim, P. K., Hur, J., Lee, H. J., Kim, Y. J., Suh, Y. J., Paek, M. Y., & Choi, B. W. (2017). Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study /692/53/2421 /692/699/75/230 /59 /59/57 /123 /128 article. Scientific reports, 7(1), [2663]. https://doi.org/10.1038/s41598-017-02627-x