Early gastric carcinoma with signet ring cell histology

WooJin Hyung, Hoon Noh Sung, Ho Lee Jun, Jihun J. Huh, Hyeok Lah Ki, Ho Choi Seung, Sik Min Jin

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

BACKGROUND. There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types. METHODS. A total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types. RESULTS. Younger patients more often had SRC than non-SRC. Additionally, the proportion of females was greater in SRC than in non-SRC. Signet ring cell carcinoma had a larger proportion of mucosa-confined lesions and a lower rate of lymph node metastasis than non-SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non-SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non-SRC (P = 0.0104). CONCLUSIONS. Early gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalCancer
Volume94
Issue number1
DOIs
Publication statusPublished - 2002 Jan 1

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Signet Ring Cell Carcinoma
Stomach
Histology
Carcinoma
Lymph Nodes
Neoplasm Metastasis
Gastrectomy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Hyung, W., Sung, H. N., Jun, H. L., Huh, J. J., Ki, H. L., Seung, H. C., & Jin, S. M. (2002). Early gastric carcinoma with signet ring cell histology. Cancer, 94(1), 78-83. https://doi.org/10.1002/cncr.10120
Hyung, WooJin ; Sung, Hoon Noh ; Jun, Ho Lee ; Huh, Jihun J. ; Ki, Hyeok Lah ; Seung, Ho Choi ; Jin, Sik Min. / Early gastric carcinoma with signet ring cell histology. In: Cancer. 2002 ; Vol. 94, No. 1. pp. 78-83.
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Hyung, W, Sung, HN, Jun, HL, Huh, JJ, Ki, HL, Seung, HC & Jin, SM 2002, 'Early gastric carcinoma with signet ring cell histology', Cancer, vol. 94, no. 1, pp. 78-83. https://doi.org/10.1002/cncr.10120

Early gastric carcinoma with signet ring cell histology. / Hyung, WooJin; Sung, Hoon Noh; Jun, Ho Lee; Huh, Jihun J.; Ki, Hyeok Lah; Seung, Ho Choi; Jin, Sik Min.

In: Cancer, Vol. 94, No. 1, 01.01.2002, p. 78-83.

Research output: Contribution to journalArticle

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AU - Hyung, WooJin

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AU - Jun, Ho Lee

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N2 - BACKGROUND. There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types. METHODS. A total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types. RESULTS. Younger patients more often had SRC than non-SRC. Additionally, the proportion of females was greater in SRC than in non-SRC. Signet ring cell carcinoma had a larger proportion of mucosa-confined lesions and a lower rate of lymph node metastasis than non-SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non-SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non-SRC (P = 0.0104). CONCLUSIONS. Early gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life.

AB - BACKGROUND. There has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types. METHODS. A total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types. RESULTS. Younger patients more often had SRC than non-SRC. Additionally, the proportion of females was greater in SRC than in non-SRC. Signet ring cell carcinoma had a larger proportion of mucosa-confined lesions and a lower rate of lymph node metastasis than non-SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non-SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non-SRC (P = 0.0104). CONCLUSIONS. Early gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life.

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Hyung W, Sung HN, Jun HL, Huh JJ, Ki HL, Seung HC et al. Early gastric carcinoma with signet ring cell histology. Cancer. 2002 Jan 1;94(1):78-83. https://doi.org/10.1002/cncr.10120