Early Repolarization Pattern in Patients with Vasospastic Angina Is Related to Sudden Cardiac Death and Fatal Ventricular Arrhythmia

Chang Myung Oh, Jaewon Oh, Hye Jin Hwang, Jong Yun Kim, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung

Research output: Contribution to journalArticle

Abstract

Background: This study was performed to investigate the prevalence and prognostic significance of early repolarization (ER) in patients with vasospastic angina (VA). Methods: We assessed the prevalence and prognostic significance of ER in 693 VA patients (age 51 ±9 years). The control group consisted of 1,189 age- and sex-matched healthy control. The primary end point was death from all causes, and secondary end points were aborted sudden cardiac death or fatal ventricular arrhythmia. Results: ER was more common in VA (36.9% [n=256]) than in control (5.5% [n=65], p<0.001). VA patients with ER (ER group) were more likely to be men (65% vs. 56%, p=0.017) than those without ER (Non-ER group). Although there was no difference in primary end point, secondary end points were more frequently observed as the initial presentation (2.7% vs. 0.7%, p=0.044), and during the mean follow up period of 86.7± 51.3 months (3.5% versus 0.9%, p=0.02) in the ER than in the non-ER group. A J-point elevation of more than 0.1 mV in the inferior leads was associated with an increased risk of secondary end points (HR 4.00,1.5210.55; p=0.005). Conclusion: ER was more frequently observed and associated with an increased risk of aborted sudden cardiac death or fatal ventricular arrhythmia in VA patients.

Original languageEnglish
Number of pages1
Journaljournal of arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

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Sudden Cardiac Death
Cardiac Arrhythmias
Cause of Death
Control Groups

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{9013d36309fe4dbfa0eae67fcf2d1889,
title = "Early Repolarization Pattern in Patients with Vasospastic Angina Is Related to Sudden Cardiac Death and Fatal Ventricular Arrhythmia",
abstract = "Background: This study was performed to investigate the prevalence and prognostic significance of early repolarization (ER) in patients with vasospastic angina (VA). Methods: We assessed the prevalence and prognostic significance of ER in 693 VA patients (age 51 ±9 years). The control group consisted of 1,189 age- and sex-matched healthy control. The primary end point was death from all causes, and secondary end points were aborted sudden cardiac death or fatal ventricular arrhythmia. Results: ER was more common in VA (36.9{\%} [n=256]) than in control (5.5{\%} [n=65], p<0.001). VA patients with ER (ER group) were more likely to be men (65{\%} vs. 56{\%}, p=0.017) than those without ER (Non-ER group). Although there was no difference in primary end point, secondary end points were more frequently observed as the initial presentation (2.7{\%} vs. 0.7{\%}, p=0.044), and during the mean follow up period of 86.7± 51.3 months (3.5{\%} versus 0.9{\%}, p=0.02) in the ER than in the non-ER group. A J-point elevation of more than 0.1 mV in the inferior leads was associated with an increased risk of secondary end points (HR 4.00,1.5210.55; p=0.005). Conclusion: ER was more frequently observed and associated with an increased risk of aborted sudden cardiac death or fatal ventricular arrhythmia in VA patients.",
author = "Oh, {Chang Myung} and Jaewon Oh and Hwang, {Hye Jin} and Kim, {Jong Yun} and Pak, {Hui Nam} and Lee, {Moon Hyoung} and Boyoung Joung",
year = "2011",
month = "1",
day = "1",
doi = "10.4020/jhrs.27.OP67_1",
language = "English",
volume = "27",
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Early Repolarization Pattern in Patients with Vasospastic Angina Is Related to Sudden Cardiac Death and Fatal Ventricular Arrhythmia. / Oh, Chang Myung; Oh, Jaewon; Hwang, Hye Jin; Kim, Jong Yun; Pak, Hui Nam; Lee, Moon Hyoung; Joung, Boyoung.

In: journal of arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Early Repolarization Pattern in Patients with Vasospastic Angina Is Related to Sudden Cardiac Death and Fatal Ventricular Arrhythmia

AU - Oh, Chang Myung

AU - Oh, Jaewon

AU - Hwang, Hye Jin

AU - Kim, Jong Yun

AU - Pak, Hui Nam

AU - Lee, Moon Hyoung

AU - Joung, Boyoung

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: This study was performed to investigate the prevalence and prognostic significance of early repolarization (ER) in patients with vasospastic angina (VA). Methods: We assessed the prevalence and prognostic significance of ER in 693 VA patients (age 51 ±9 years). The control group consisted of 1,189 age- and sex-matched healthy control. The primary end point was death from all causes, and secondary end points were aborted sudden cardiac death or fatal ventricular arrhythmia. Results: ER was more common in VA (36.9% [n=256]) than in control (5.5% [n=65], p<0.001). VA patients with ER (ER group) were more likely to be men (65% vs. 56%, p=0.017) than those without ER (Non-ER group). Although there was no difference in primary end point, secondary end points were more frequently observed as the initial presentation (2.7% vs. 0.7%, p=0.044), and during the mean follow up period of 86.7± 51.3 months (3.5% versus 0.9%, p=0.02) in the ER than in the non-ER group. A J-point elevation of more than 0.1 mV in the inferior leads was associated with an increased risk of secondary end points (HR 4.00,1.5210.55; p=0.005). Conclusion: ER was more frequently observed and associated with an increased risk of aborted sudden cardiac death or fatal ventricular arrhythmia in VA patients.

AB - Background: This study was performed to investigate the prevalence and prognostic significance of early repolarization (ER) in patients with vasospastic angina (VA). Methods: We assessed the prevalence and prognostic significance of ER in 693 VA patients (age 51 ±9 years). The control group consisted of 1,189 age- and sex-matched healthy control. The primary end point was death from all causes, and secondary end points were aborted sudden cardiac death or fatal ventricular arrhythmia. Results: ER was more common in VA (36.9% [n=256]) than in control (5.5% [n=65], p<0.001). VA patients with ER (ER group) were more likely to be men (65% vs. 56%, p=0.017) than those without ER (Non-ER group). Although there was no difference in primary end point, secondary end points were more frequently observed as the initial presentation (2.7% vs. 0.7%, p=0.044), and during the mean follow up period of 86.7± 51.3 months (3.5% versus 0.9%, p=0.02) in the ER than in the non-ER group. A J-point elevation of more than 0.1 mV in the inferior leads was associated with an increased risk of secondary end points (HR 4.00,1.5210.55; p=0.005). Conclusion: ER was more frequently observed and associated with an increased risk of aborted sudden cardiac death or fatal ventricular arrhythmia in VA patients.

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DO - 10.4020/jhrs.27.OP67_1

M3 - Article

AN - SCOPUS:85009548044

VL - 27

JO - Journal of Arrhythmia

JF - Journal of Arrhythmia

SN - 1880-4276

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