Early sleep deprivation and attention-deficit/hyperactivity disorder

Winnie Tso, Meanne Chan, Frederick K. Ho, Nirmala Rao, Albert M. Li, Ko Ling Chan, Agnes Tiwari, Ian C.K. Wong, Yun Kwok Wing, Benjamin Van Voorhees, Sophia Ling Li, Winnie H.S. Goh, Patrick Ip

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: This study aims to study prospectively specific sleep patterns and risk of ADHD after adjusting for potential confounders such as obstructive sleep apnoea (OSA) and methylphenidate use. Methods: A population-representative sample of 514 Chinese preschool children was recruited when in kindergarten (K3). Parents reported on their socioeconomic status and children’s sleep duration. The cohort was reassessed 3 years later when the children were in Grade 3 (P3). Parents reported on children’s sleep patterns and ADHD symptoms. Information on OSA diagnosis and methylphenidate use was retrieved from health records. Results: Among the 514 parent–child dyads (mean [SD] age, 5.52 [0.33] years), 411 were reassessed (80.0% retention; 9.35 [0.33] years) at follow-up. There were no significant baseline differences between follow-up and drop-out groups. A gradient relationship was observed between probable ADHD in P3 and sleep duration in K3. The risk of probable ADHD was 15.5 per 100 for children with <8 h of sleep in K3, whereas it was 1.1 per 100 for children with 11–12 h of sleep in K3. The adjusted risk ratio was 14.19 (p = 0.02). Conclusions: Sleep deprivation in early childhood is associated with higher risk of ADHD in middle childhood.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalPediatric Research
Volume85
Issue number4
DOIs
Publication statusPublished - 2019 Mar 1

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Sleep Deprivation
Attention Deficit Disorder with Hyperactivity
Sleep
Methylphenidate
Obstructive Sleep Apnea
Parents
Preschool Children
Social Class
Odds Ratio
Health
Population

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Tso, W., Chan, M., Ho, F. K., Rao, N., Li, A. M., Chan, K. L., ... Ip, P. (2019). Early sleep deprivation and attention-deficit/hyperactivity disorder. Pediatric Research, 85(4), 449-455. https://doi.org/10.1038/s41390-019-0280-4
Tso, Winnie ; Chan, Meanne ; Ho, Frederick K. ; Rao, Nirmala ; Li, Albert M. ; Chan, Ko Ling ; Tiwari, Agnes ; Wong, Ian C.K. ; Wing, Yun Kwok ; Van Voorhees, Benjamin ; Li, Sophia Ling ; Goh, Winnie H.S. ; Ip, Patrick. / Early sleep deprivation and attention-deficit/hyperactivity disorder. In: Pediatric Research. 2019 ; Vol. 85, No. 4. pp. 449-455.
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Tso, W, Chan, M, Ho, FK, Rao, N, Li, AM, Chan, KL, Tiwari, A, Wong, ICK, Wing, YK, Van Voorhees, B, Li, SL, Goh, WHS & Ip, P 2019, 'Early sleep deprivation and attention-deficit/hyperactivity disorder', Pediatric Research, vol. 85, no. 4, pp. 449-455. https://doi.org/10.1038/s41390-019-0280-4

Early sleep deprivation and attention-deficit/hyperactivity disorder. / Tso, Winnie; Chan, Meanne; Ho, Frederick K.; Rao, Nirmala; Li, Albert M.; Chan, Ko Ling; Tiwari, Agnes; Wong, Ian C.K.; Wing, Yun Kwok; Van Voorhees, Benjamin; Li, Sophia Ling; Goh, Winnie H.S.; Ip, Patrick.

In: Pediatric Research, Vol. 85, No. 4, 01.03.2019, p. 449-455.

Research output: Contribution to journalArticle

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T1 - Early sleep deprivation and attention-deficit/hyperactivity disorder

AU - Tso, Winnie

AU - Chan, Meanne

AU - Ho, Frederick K.

AU - Rao, Nirmala

AU - Li, Albert M.

AU - Chan, Ko Ling

AU - Tiwari, Agnes

AU - Wong, Ian C.K.

AU - Wing, Yun Kwok

AU - Van Voorhees, Benjamin

AU - Li, Sophia Ling

AU - Goh, Winnie H.S.

AU - Ip, Patrick

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: This study aims to study prospectively specific sleep patterns and risk of ADHD after adjusting for potential confounders such as obstructive sleep apnoea (OSA) and methylphenidate use. Methods: A population-representative sample of 514 Chinese preschool children was recruited when in kindergarten (K3). Parents reported on their socioeconomic status and children’s sleep duration. The cohort was reassessed 3 years later when the children were in Grade 3 (P3). Parents reported on children’s sleep patterns and ADHD symptoms. Information on OSA diagnosis and methylphenidate use was retrieved from health records. Results: Among the 514 parent–child dyads (mean [SD] age, 5.52 [0.33] years), 411 were reassessed (80.0% retention; 9.35 [0.33] years) at follow-up. There were no significant baseline differences between follow-up and drop-out groups. A gradient relationship was observed between probable ADHD in P3 and sleep duration in K3. The risk of probable ADHD was 15.5 per 100 for children with <8 h of sleep in K3, whereas it was 1.1 per 100 for children with 11–12 h of sleep in K3. The adjusted risk ratio was 14.19 (p = 0.02). Conclusions: Sleep deprivation in early childhood is associated with higher risk of ADHD in middle childhood.

AB - Background: This study aims to study prospectively specific sleep patterns and risk of ADHD after adjusting for potential confounders such as obstructive sleep apnoea (OSA) and methylphenidate use. Methods: A population-representative sample of 514 Chinese preschool children was recruited when in kindergarten (K3). Parents reported on their socioeconomic status and children’s sleep duration. The cohort was reassessed 3 years later when the children were in Grade 3 (P3). Parents reported on children’s sleep patterns and ADHD symptoms. Information on OSA diagnosis and methylphenidate use was retrieved from health records. Results: Among the 514 parent–child dyads (mean [SD] age, 5.52 [0.33] years), 411 were reassessed (80.0% retention; 9.35 [0.33] years) at follow-up. There were no significant baseline differences between follow-up and drop-out groups. A gradient relationship was observed between probable ADHD in P3 and sleep duration in K3. The risk of probable ADHD was 15.5 per 100 for children with <8 h of sleep in K3, whereas it was 1.1 per 100 for children with 11–12 h of sleep in K3. The adjusted risk ratio was 14.19 (p = 0.02). Conclusions: Sleep deprivation in early childhood is associated with higher risk of ADHD in middle childhood.

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