Echocardiographic features in patients with ANCA-associated vasculitis within 3 months before and after diagnosis

Sung Soo Ahn, Eun Seong Park, Seung Min Jung, Jason Jungsik Song, YongBeom Park, Sang Won Lee

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Abstract

We investigated the all-inclusive echocardiographic features in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) within 3 months before and after diagnosis. We reviewed the medical records of 89 AAV patients taking echocardiography and 35 age- and gender-matched controls. We collected clinical and laboratory data and echocardiographic results. We compared the variables between patients with AAV of each variant and controls and among those with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA). The mean age and period from diagnosis to echocardiography were 54.5 years (30 men) and 1.4 months. The mean age of controls was 51.6 years. AAV patients exhibited lower mean left ventricle ejection fraction (LVEF) (64.0 vs. 69.1%, P = 0.002) and higher mean E/E′ ratio (11.7 vs. 8.8, P = 0.001) and right ventricle systolic pressure (RVSP) (30.2 vs. 23.2 mm Hg, P < 0.001) than the controls. Each variant of AAV presented a different pattern of echocardiographic features in comparison with controls. MPA patients exhibited systolic and diastolic dysfunctions and pulmonary arterial hypertension more often than controls. Meanwhile, GPA patients exhibited only diastolic dysfunction, and EGPA patients had systolic dysfunction and pulmonary arterial hypertension more frequently than controls. No meaningful differences in echocardiographic features appeared among AAV variants. AAV patients exhibited reduced systolic function and advanced diastolic dysfunctions and pulmonary arterial hypertension near the time of diagnosis compared with controls. Each variant of AAV presented a different pattern in echocardiographic features.

Original languageEnglish
Pages (from-to)2751-2759
Number of pages9
JournalClinical Rheumatology
Volume36
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1

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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Antineutrophil Cytoplasmic Antibodies
Vasculitis
Granulomatosis with Polyangiitis
Microscopic Polyangiitis
Pulmonary Hypertension
Heart Ventricles
Echocardiography
Medical Records
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Ahn, Sung Soo ; Park, Eun Seong ; Jung, Seung Min ; Song, Jason Jungsik ; Park, YongBeom ; Lee, Sang Won. / Echocardiographic features in patients with ANCA-associated vasculitis within 3 months before and after diagnosis. In: Clinical Rheumatology. 2017 ; Vol. 36, No. 12. pp. 2751-2759.
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abstract = "We investigated the all-inclusive echocardiographic features in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) within 3 months before and after diagnosis. We reviewed the medical records of 89 AAV patients taking echocardiography and 35 age- and gender-matched controls. We collected clinical and laboratory data and echocardiographic results. We compared the variables between patients with AAV of each variant and controls and among those with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA). The mean age and period from diagnosis to echocardiography were 54.5 years (30 men) and 1.4 months. The mean age of controls was 51.6 years. AAV patients exhibited lower mean left ventricle ejection fraction (LVEF) (64.0 vs. 69.1{\%}, P = 0.002) and higher mean E/E′ ratio (11.7 vs. 8.8, P = 0.001) and right ventricle systolic pressure (RVSP) (30.2 vs. 23.2 mm Hg, P < 0.001) than the controls. Each variant of AAV presented a different pattern of echocardiographic features in comparison with controls. MPA patients exhibited systolic and diastolic dysfunctions and pulmonary arterial hypertension more often than controls. Meanwhile, GPA patients exhibited only diastolic dysfunction, and EGPA patients had systolic dysfunction and pulmonary arterial hypertension more frequently than controls. No meaningful differences in echocardiographic features appeared among AAV variants. AAV patients exhibited reduced systolic function and advanced diastolic dysfunctions and pulmonary arterial hypertension near the time of diagnosis compared with controls. Each variant of AAV presented a different pattern in echocardiographic features.",
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Echocardiographic features in patients with ANCA-associated vasculitis within 3 months before and after diagnosis. / Ahn, Sung Soo; Park, Eun Seong; Jung, Seung Min; Song, Jason Jungsik; Park, YongBeom; Lee, Sang Won.

In: Clinical Rheumatology, Vol. 36, No. 12, 01.12.2017, p. 2751-2759.

Research output: Contribution to journalArticle

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