Echogenic carotid artery plaques are associated with vertebral fractures in postmenopausal women with low bone mass

Se Hwa Kim, Yoo Mee Kim, Mi Ae Cho, Yumie Rhee, Kyu Yeon Hur, Eun Seok Kang, Bong Soo Cha, Eunjig Lee, Hyun Chul Lee, Sungkil Lim

Research output: Contribution to journalArticle

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Abstract

Although low bone mass has been associated with atherosclerosis even after adjustment for age, little is known about the association between vertebral fractures and calcified atherosclerotic plaques. Our objective was to investigate whether osteoporotic vertebral fractures are independently related to the prevalence of atherosclerotic carotid plaques in postmenopausal women with low bone mass. We enrolled 195 postmenopausal women with osteopenia or osteoporosis. Bone mineral density and the presence of vertebral fractures were assessed. Intima media thickness and atherosclerotic plaques of the carotid artery were assessed using ultrasonography. Of the 195 subjects in the study, 84 had no plaques and 111 had at least one. The percentage of women with vertebral fractures was significantly higher in subjects with echogenic carotid plaques than in those without (27% vs. 11%, respectively; P < 0.05). However, there was no difference in the prevalence of vertebral fractures between women with echolucent plaques and those without (10.9% vs. 10.7%, respectively; P = nonsignificant). By logistic regression analysis with multivariate adjustment, age (P < 0.01), dyslipidemia (P < 0.05), and the presence of vertebral fracture (P < 0.05) were independent risk factors for echogenic carotid plaques. Osteoporotic vertebral fractures are associated with an increased risk of echogenic atherosclerotic plaques in postmenopausal women with low bone mass. It appears that the high association of echogenic atherosclerotic plaques and vertebral fractures could partially explain why osteoporotic vertebral fractures are linked to increased mortality.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalCalcified Tissue International
Volume82
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1

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Carotid Stenosis
Atherosclerotic Plaques
Osteoporotic Fractures
Bone and Bones
Metabolic Bone Diseases
Dyslipidemias
Carotid Arteries
Bone Density
Osteoporosis
Ultrasonography
Atherosclerosis
Logistic Models
Regression Analysis
Mortality

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Kim, Se Hwa ; Kim, Yoo Mee ; Cho, Mi Ae ; Rhee, Yumie ; Hur, Kyu Yeon ; Kang, Eun Seok ; Cha, Bong Soo ; Lee, Eunjig ; Lee, Hyun Chul ; Lim, Sungkil. / Echogenic carotid artery plaques are associated with vertebral fractures in postmenopausal women with low bone mass. In: Calcified Tissue International. 2008 ; Vol. 82, No. 6. pp. 411-417.
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Echogenic carotid artery plaques are associated with vertebral fractures in postmenopausal women with low bone mass. / Kim, Se Hwa; Kim, Yoo Mee; Cho, Mi Ae; Rhee, Yumie; Hur, Kyu Yeon; Kang, Eun Seok; Cha, Bong Soo; Lee, Eunjig; Lee, Hyun Chul; Lim, Sungkil.

In: Calcified Tissue International, Vol. 82, No. 6, 01.06.2008, p. 411-417.

Research output: Contribution to journalArticle

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AU - Kim, Se Hwa

AU - Kim, Yoo Mee

AU - Cho, Mi Ae

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AU - Hur, Kyu Yeon

AU - Kang, Eun Seok

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AU - Lim, Sungkil

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