Effect of 0.2% brimonidine in preventing intraocular pressure elevation after Nd:YAG laser posterior capsulotomy

Gong Je Seong, Young Ghee Lee, Jong Hyuk Lee, Seung Jeong Lim, Sung Chul Lee, Young Jae Hong, Oh Woong Kwon, Hong Bok Kim

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Abstract

BACKGROUND AND OBJECTIVE: To determine the prophylactic effect of 0.2% brimonidine in reducing the elevated intraocular pressure (IOP) in patients undergoing Nd:YAG laser posterior capsulotomy. PATIENTS AND METHODS: The 81 patients (81 eyes), who underwent Nd:YAG laser posterior capsulotomy, were allocated to two treatment groups. One drop of 0.2% brimonidine or vehicle was instilled 1 hour preoperatively and one drop immediately after capsulotomy, IOPs were measured preoperatively and 1, 2, 3, and 24 hours postoperatively. RESULTS: Intraocular pressure decreased from the baseline in the brimonidine group by the third postoperative hour (P<0.05), while the vehicle group exhibited an increase. Intraocular pressure elevations of 5 mm Hg or greater occurred in 7.3% (3/41) in the brimonidine group compared to 20.0% (8/40) in the vehicle group. IOP elevations of 10 mm Hg or greater occurred in 2.4% (1/41) in the brimonidine group compared to 7.5% (3/40) in the vehicle group. CONCLUSIONS: One drop of 0.2% brimonidine instilled 1 hour preoperatively and immediately after capsulotomy was found to be efficacious and safe in preventing IOP elevations that frequently follow Nd:YAG laser posterior capsulotomy.

Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalOphthalmic Surgery and Lasers
Volume31
Issue number4
Publication statusPublished - 2000 Jul 1

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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    Seong, G. J., Lee, Y. G., Lee, J. H., Lim, S. J., Lee, S. C., Hong, Y. J., Kwon, O. W., & Kim, H. B. (2000). Effect of 0.2% brimonidine in preventing intraocular pressure elevation after Nd:YAG laser posterior capsulotomy. Ophthalmic Surgery and Lasers, 31(4), 308-314.