Effect of (1→3)(1→6)-B-glucan containing PLGA scaffold on human dermal fibroblast attachment and proliferation

Sang Gil Lee, Jung Bok Lee, Jong Chul Park, Young I.I. Yang, Jeong Koo Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of β-glucan-reinforced PLGA scaffold on cell proliferation was investigated. The PLGA scaffolds were prepared by salt-leaching method. The prepared scaffolds were grafted with (1→3) (1→6)-β-glucan in various ratios after plasma treatment on the surface. The surface of the scaffold was characterized by scanning electron microscope (SEM). The HDFs (Human dermal fibroblasts, 1 × 105 cells/scaffold) were used to evaluate the cell proliferation on PLGA scaffold before and after plasma/β-glucan treatment. In results, in the β-glucan treated scaffolds, the pores seemed to become narrower and even looked like closed form. The result of cell proliferation showed that the plasma/β-glucan treated scaffolds had narrower pores because the β-glucan was attached in the pores that would not be allowed the cells to penetrate into the inner areas. Consequently, cell proliferation was not effective in the plasma/β-glucan treated scaffolds in this study.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 17

Fingerprint

Glucans
Fibroblasts
Scaffolds
Cell proliferation
Scaffolds (biology)
Plasmas
Leaching
Electron microscopes
polylactic acid-polyglycolic acid copolymer
Salts
Scanning

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Lee, Sang Gil ; Lee, Jung Bok ; Park, Jong Chul ; Yang, Young I.I. ; Kim, Jeong Koo. / Effect of (1→3)(1→6)-B-glucan containing PLGA scaffold on human dermal fibroblast attachment and proliferation. In: Key Engineering Materials. 2007 ; Vol. 342-343. pp. 377-380.
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Effect of (1→3)(1→6)-B-glucan containing PLGA scaffold on human dermal fibroblast attachment and proliferation. / Lee, Sang Gil; Lee, Jung Bok; Park, Jong Chul; Yang, Young I.I.; Kim, Jeong Koo.

In: Key Engineering Materials, Vol. 342-343, 17.04.2007, p. 377-380.

Research output: Contribution to journalArticle

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AU - Lee, Jung Bok

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AU - Kim, Jeong Koo

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AB - The effect of β-glucan-reinforced PLGA scaffold on cell proliferation was investigated. The PLGA scaffolds were prepared by salt-leaching method. The prepared scaffolds were grafted with (1→3) (1→6)-β-glucan in various ratios after plasma treatment on the surface. The surface of the scaffold was characterized by scanning electron microscope (SEM). The HDFs (Human dermal fibroblasts, 1 × 105 cells/scaffold) were used to evaluate the cell proliferation on PLGA scaffold before and after plasma/β-glucan treatment. In results, in the β-glucan treated scaffolds, the pores seemed to become narrower and even looked like closed form. The result of cell proliferation showed that the plasma/β-glucan treated scaffolds had narrower pores because the β-glucan was attached in the pores that would not be allowed the cells to penetrate into the inner areas. Consequently, cell proliferation was not effective in the plasma/β-glucan treated scaffolds in this study.

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