Effect of 6,7-dimethoxy-2,2-dimethyl-2h-chromene (Agerarin) on the recovery of filaggrin expression through targeting of janus kinases in the inflammatory skin

Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Filaggrin (FLG) is a structural component of the stratum corneum that is essential for maintaining the barrier function of the skin and for the formation of natural moisturizing factors. 6,7-Dimethoxy-2,2-dimethyl-2H-chromene (Agerarin) is a bioactive compound derived from Ageratum houstonianum, a plant that is used as a traditional medicine to treat skin diseases. This study aimed to evaluate the effect of agerarin on skin inflammation in a dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. We found that the topical administration of agerarin ameliorates atopic dermatitis-like skin lesions. We also showed that agerarin restores the reduced filaggrin (FLG) expression in DNCB-applied skin sections. Moreover, agerarin decreased phosphorylation of JAK1 and JAK2 kinases to enhance FLG expression, which was reduced by TNFα+IFNγ and IL4+IL13 treatment, in HaCaT keratinocytes. These results demonstrate the feasibility of agerarin as a possible therapeutic against conditions of skin inflammation, such as atopic dermatitis, by improving the upregulation of FLG expression.

Original languageEnglish
Article number6
Pages (from-to)449-460
Number of pages12
JournalJournal of Food and Drug Analysis
Volume28
Issue number3
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This paper was supported by Konkuk University in 2016. We would like to thank Editage (www.editage.co.kr) for English language editing.

Funding Information:
This paper was supported by Konkuk University in 2016.

Publisher Copyright:
© 2020, Taiwan Food and Drug Administration. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Food Science
  • Pharmacology

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