Effect of a ketogenic diet on EEG: Analysis of sample entropy

Myung Kul Yum, Ki Young Jung, Hoon Chul Kang, Heung Dong Kim, Young Min Shon, Joong Ku Kang, Il Keun Lee, Ki Jong Park, Oh Young Kwon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Although ketogenic diet (KD) is an effective alternative therapy for controlling intractable seizures, the anticonvulsant mechanism still remains unclear. Sample entropy (SampEn) provides a generalized measure of regularity in time-series data. To investigate the potential anticonvulsive mechanism of a KD, we analyzed the SampEn of electroencephalography (EEG) data in patients with intractable pediatric epilepsy before and after treatment with a KD. Seventeen pediatric patients with epilepsy who were treated with KD were enrolled in present study. Patients were classified as good responder and poor responder according to therapeutic responsiveness on KD. Thirty segments of 30-s epochs were selected before and after KD from each patient which were subject to SampEn. The KD increased the SampEn in the whole patient population; the SampEn increased significantly in all electrodes in the good responders, but the change in SampEn varied according to the electrode in the poor responders. Before the KD, the good responders had significantly lower SampEn values than the poor responders, but after the KD, SampEn values were higher in the good responders than in the poor responders. KD may have an anticonvulsive effect by decreasing the regularity of the EEG dynamics.

Original languageEnglish
Pages (from-to)561-566
Number of pages6
JournalSeizure
Volume17
Issue number6
DOIs
Publication statusPublished - 2008 Sep 1

Fingerprint

Ketogenic Diet
Entropy
Electroencephalography
Electrodes
Pediatrics
Complementary Therapies
Anticonvulsants
Epilepsy
Seizures

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Yum, M. K., Jung, K. Y., Kang, H. C., Kim, H. D., Shon, Y. M., Kang, J. K., ... Kwon, O. Y. (2008). Effect of a ketogenic diet on EEG: Analysis of sample entropy. Seizure, 17(6), 561-566. https://doi.org/10.1016/j.seizure.2008.02.007
Yum, Myung Kul ; Jung, Ki Young ; Kang, Hoon Chul ; Kim, Heung Dong ; Shon, Young Min ; Kang, Joong Ku ; Lee, Il Keun ; Park, Ki Jong ; Kwon, Oh Young. / Effect of a ketogenic diet on EEG : Analysis of sample entropy. In: Seizure. 2008 ; Vol. 17, No. 6. pp. 561-566.
@article{6b94b32ba2b6475e81defd0a8803d586,
title = "Effect of a ketogenic diet on EEG: Analysis of sample entropy",
abstract = "Although ketogenic diet (KD) is an effective alternative therapy for controlling intractable seizures, the anticonvulsant mechanism still remains unclear. Sample entropy (SampEn) provides a generalized measure of regularity in time-series data. To investigate the potential anticonvulsive mechanism of a KD, we analyzed the SampEn of electroencephalography (EEG) data in patients with intractable pediatric epilepsy before and after treatment with a KD. Seventeen pediatric patients with epilepsy who were treated with KD were enrolled in present study. Patients were classified as good responder and poor responder according to therapeutic responsiveness on KD. Thirty segments of 30-s epochs were selected before and after KD from each patient which were subject to SampEn. The KD increased the SampEn in the whole patient population; the SampEn increased significantly in all electrodes in the good responders, but the change in SampEn varied according to the electrode in the poor responders. Before the KD, the good responders had significantly lower SampEn values than the poor responders, but after the KD, SampEn values were higher in the good responders than in the poor responders. KD may have an anticonvulsive effect by decreasing the regularity of the EEG dynamics.",
author = "Yum, {Myung Kul} and Jung, {Ki Young} and Kang, {Hoon Chul} and Kim, {Heung Dong} and Shon, {Young Min} and Kang, {Joong Ku} and Lee, {Il Keun} and Park, {Ki Jong} and Kwon, {Oh Young}",
year = "2008",
month = "9",
day = "1",
doi = "10.1016/j.seizure.2008.02.007",
language = "English",
volume = "17",
pages = "561--566",
journal = "Seizure : the journal of the British Epilepsy Association",
issn = "1059-1311",
publisher = "W.B. Saunders Ltd",
number = "6",

}

Yum, MK, Jung, KY, Kang, HC, Kim, HD, Shon, YM, Kang, JK, Lee, IK, Park, KJ & Kwon, OY 2008, 'Effect of a ketogenic diet on EEG: Analysis of sample entropy', Seizure, vol. 17, no. 6, pp. 561-566. https://doi.org/10.1016/j.seizure.2008.02.007

Effect of a ketogenic diet on EEG : Analysis of sample entropy. / Yum, Myung Kul; Jung, Ki Young; Kang, Hoon Chul; Kim, Heung Dong; Shon, Young Min; Kang, Joong Ku; Lee, Il Keun; Park, Ki Jong; Kwon, Oh Young.

In: Seizure, Vol. 17, No. 6, 01.09.2008, p. 561-566.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of a ketogenic diet on EEG

T2 - Analysis of sample entropy

AU - Yum, Myung Kul

AU - Jung, Ki Young

AU - Kang, Hoon Chul

AU - Kim, Heung Dong

AU - Shon, Young Min

AU - Kang, Joong Ku

AU - Lee, Il Keun

AU - Park, Ki Jong

AU - Kwon, Oh Young

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Although ketogenic diet (KD) is an effective alternative therapy for controlling intractable seizures, the anticonvulsant mechanism still remains unclear. Sample entropy (SampEn) provides a generalized measure of regularity in time-series data. To investigate the potential anticonvulsive mechanism of a KD, we analyzed the SampEn of electroencephalography (EEG) data in patients with intractable pediatric epilepsy before and after treatment with a KD. Seventeen pediatric patients with epilepsy who were treated with KD were enrolled in present study. Patients were classified as good responder and poor responder according to therapeutic responsiveness on KD. Thirty segments of 30-s epochs were selected before and after KD from each patient which were subject to SampEn. The KD increased the SampEn in the whole patient population; the SampEn increased significantly in all electrodes in the good responders, but the change in SampEn varied according to the electrode in the poor responders. Before the KD, the good responders had significantly lower SampEn values than the poor responders, but after the KD, SampEn values were higher in the good responders than in the poor responders. KD may have an anticonvulsive effect by decreasing the regularity of the EEG dynamics.

AB - Although ketogenic diet (KD) is an effective alternative therapy for controlling intractable seizures, the anticonvulsant mechanism still remains unclear. Sample entropy (SampEn) provides a generalized measure of regularity in time-series data. To investigate the potential anticonvulsive mechanism of a KD, we analyzed the SampEn of electroencephalography (EEG) data in patients with intractable pediatric epilepsy before and after treatment with a KD. Seventeen pediatric patients with epilepsy who were treated with KD were enrolled in present study. Patients were classified as good responder and poor responder according to therapeutic responsiveness on KD. Thirty segments of 30-s epochs were selected before and after KD from each patient which were subject to SampEn. The KD increased the SampEn in the whole patient population; the SampEn increased significantly in all electrodes in the good responders, but the change in SampEn varied according to the electrode in the poor responders. Before the KD, the good responders had significantly lower SampEn values than the poor responders, but after the KD, SampEn values were higher in the good responders than in the poor responders. KD may have an anticonvulsive effect by decreasing the regularity of the EEG dynamics.

UR - http://www.scopus.com/inward/record.url?scp=48449087984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48449087984&partnerID=8YFLogxK

U2 - 10.1016/j.seizure.2008.02.007

DO - 10.1016/j.seizure.2008.02.007

M3 - Article

C2 - 18396066

AN - SCOPUS:48449087984

VL - 17

SP - 561

EP - 566

JO - Seizure : the journal of the British Epilepsy Association

JF - Seizure : the journal of the British Epilepsy Association

SN - 1059-1311

IS - 6

ER -