Effect of a new combined therapy with nano-carbonate apatite and CO 2 laser on dentin hypersensitivity in an in situ model

Sun Young Han, Ji Sun Kim, Young Seok Kim, Ho Keun Kwon, Baek Il Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: The aim of this study was to determine the occluding effects of a combination of dentifrice containing nano-carbonate apatite (n-CAP) and CO2 laser on dentinal tubules, and to evaluate the acid resistance of this combination after 4 days of treatment, by using an in situ model. Background data: The synergic effect of this combination was demonstrated in an in vitro study. Methods: This was a two period crossover, single-blind, randomized, four-treatment, split-mouth study. Ten healthy participants wore lower intraoral appliances during the treatment period. Specimens were divided into the following four groups: no treatment (control group), tooth-brushing using 20% n-CAP dentifrice (n-CAP group), CO2 laser irradiation (laser group), and laser irradiation after n-CAP application (combined group). Occluding effects were evaluated on 2 days (days 1 and 2), and then acid challenge was performed using grape juice on 2 days (days 3 and 4). All of the specimen surfaces were evaluated by a scanning electron microscope. Results: The combined group showed a better occluding effect than control group compared with other treatment groups, and this effect was 20% higher than that in the n-CAP group. Also, the combined group had the smallest open dentinal tubular area among all of the treatment groups. Conclusions: The combined therapy is a promising method for ensuring a long-lasting effect of dentin hypersensitivity treatment in clinical practice.

Original languageEnglish
Pages (from-to)394-400
Number of pages7
JournalPhotomedicine and laser surgery
Issue number7
Publication statusPublished - 2014 Jul 1

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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