Effect of a short-term physical activity intervention on liver fat content in obese children

Dong Woo Kang, Ji Hye Park, Mi Kyung Lee, Yoon Myung Kim, Indeok Kong, Choon Hee Chung, Young Hee Lee, Justin Y. Jeon

Research output: Contribution to journalArticle

Abstract

Nonalcoholic fatty liver disease is the most common chronic liver disease and can present with advanced fibrosis or nonalcoholic steatohepatitis. The purpose of this study was to investigate the effect of a 7-day intense physical activity intervention on liver fat content in children with obesity. Fifty-seven obese children (mean body mass index: 26.5± 3.2 kg/m2; mean age: 12.0± 0.8 years) participated in a 7-day physical activity program. All participants were housed together, and their food intake and energy expenditure were strictly controlled. Anthropometric measurements, abdominal computerized tomography scans, and blood analyses were conducted at baseline and post-intervention. Participants lost weight by 2.53± 0.85 kg on average (61.0± 9.8 vs. 58.5± 9.5 kg, p < 0.05), fat mass (16.7± 5.1 vs. 15.7± 4.9 kg, p < 0.05), and serum insulin (13.7± 6.7 vs. 3.5± 2.0 µU/mL, p < 0.05). However, liver fat content was increased, presented as liver-to-spleen ratio (LSR) where lower LSR represents higher liver fat content. The intervention increased aspartate transaminase level (29.42± 6.78 IU/L vs. 33.50± 9.60 IU/L, p < 0.001). The change in liver fat content was not associated with the change in fasting insulin and liver enzymes. Short-term intense physical activity increased liver fat content independent of change in fasting insulin level and liver enzymes. This is the first human study to report increased liver fat content after physical activity-induced rapid weight loss.

Original languageEnglish
Pages (from-to)553-557
Number of pages5
JournalApplied Physiology, Nutrition and Metabolism
Volume43
Issue number6
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Fats
Exercise
Liver
Insulin
Fasting
Spleen
Pediatric Obesity
Enzymes
Aspartate Aminotransferases
Energy Metabolism
Liver Diseases
Weight Loss
Body Mass Index
Fibrosis
Chronic Disease
Eating
Tomography
Weights and Measures
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

Kang, Dong Woo ; Park, Ji Hye ; Lee, Mi Kyung ; Kim, Yoon Myung ; Kong, Indeok ; Chung, Choon Hee ; Lee, Young Hee ; Jeon, Justin Y. / Effect of a short-term physical activity intervention on liver fat content in obese children. In: Applied Physiology, Nutrition and Metabolism. 2018 ; Vol. 43, No. 6. pp. 553-557.
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Effect of a short-term physical activity intervention on liver fat content in obese children. / Kang, Dong Woo; Park, Ji Hye; Lee, Mi Kyung; Kim, Yoon Myung; Kong, Indeok; Chung, Choon Hee; Lee, Young Hee; Jeon, Justin Y.

In: Applied Physiology, Nutrition and Metabolism, Vol. 43, No. 6, 01.01.2018, p. 553-557.

Research output: Contribution to journalArticle

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