The actin network plays a critical role in cellular deformations. To investigate how the filamentous structure and the characteristics of actin affect the actin network contraction induced by myosin, a computational model of actomyosin network was designed. Using the developed model, we investigated the effect of actin filament rigidity on the dynamic characteristics of the actomyosin network. Particularly, by calculating local MSD as a function of time, we found that actin filament rigidity changes the response time and the mode of the actin network contraction between superdiffusion and ballistic motions. Furthermore, the critical value of the filament rigidity which increases the network contraction speed and the contraction efficiency, was found to be similar to the rigidity of the actin in vivo.
|Number of pages||4|
|Journal||Transactions of the Korean Society of Mechanical Engineers, B|
|Publication status||Published - 2020|
Bibliographical notePublisher Copyright:
© 2020 The Korean Society of Mechanical Engineers
All Science Journal Classification (ASJC) codes
- Mechanical Engineering