Effect of adjunct balloon dilation after long everolimus-eluting stent deployment on major adverse cardiac events

Sung Jin Hong, Chul Min Ahn, Dong Ho Shin, Jung Sun Kim, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Ae Young Her, Yong Hoon Kim, Yangsoo Jang, Myeongki Hong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Objectives: The effectiveness of adjunct balloon dilation afer drug-eluting stent (DES) deployment has not been sufciently evaluated. We evaluated whether adjunct balloon dilation was associated with a reduction in major adverse cardiac events (MACEs) afer long everolimus-eluting stents (EESs) implantation. Subjects and Methods: Drawing from 2 randomized trials, a total of 1,672 patients treated with long EES were analyzed. Of 1,672 patients, 1,061 patients (64%) received post-stent adjunct balloon dilation. MACE, defned as a composite of cardiac death, myocardial infarction, and target-lesion revascularization (TLR), was compared between patients who received post-stent adjunct balloon dilation and patients who did not in 595 propensity scorematched pairs. Results: For the matched population, MACE occurred in 29 patients (4.9%) who received adjunct balloon dilation and in 29 patients (4.9%) who did not (hazard ratio [HR], 1.01; 95% confdence interval [CI], 0.60'1.69; p=0.972). However, signifcant interactions were observed among the subgroups for clinical presentation and vessel size. Adjunct balloon dilation was more favored within the subset of patients with stable angina vs. the subset of patients with acute coronary syndrome (p for interaction=0.037), and within the subset of lesions with small vessel diameter (reference vessel diameter [RVD] <3 mm) vs. the subset of lesions with larger vessel diameter (RVD =3 mm; p for interaction=0.027). Conclusion: Adjunct balloon dilation was not associated with MACE reduction at 1 year among patients requiring long EES implantation. However, post-stent adjunct balloon dilation may be necessary for patients requiring long EES implantation who present with stable angina or for lesions with small vessel diameters.

Original languageEnglish
Pages (from-to)694-704
Number of pages11
JournalKorean Circulation Journal
Volume47
Issue number5
DOIs
Publication statusPublished - 2017 Sep 1

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Stents
Dilatation
Stable Angina
Everolimus
Drug-Eluting Stents
Acute Coronary Syndrome
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Sung Jin ; Ahn, Chul Min ; Shin, Dong Ho ; Kim, Jung Sun ; Kim, Byeong Keuk ; Ko, Young Guk ; Choi, Donghoon ; Her, Ae Young ; Kim, Yong Hoon ; Jang, Yangsoo ; Hong, Myeongki. / Effect of adjunct balloon dilation after long everolimus-eluting stent deployment on major adverse cardiac events. In: Korean Circulation Journal. 2017 ; Vol. 47, No. 5. pp. 694-704.
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abstract = "Background and Objectives: The effectiveness of adjunct balloon dilation afer drug-eluting stent (DES) deployment has not been sufciently evaluated. We evaluated whether adjunct balloon dilation was associated with a reduction in major adverse cardiac events (MACEs) afer long everolimus-eluting stents (EESs) implantation. Subjects and Methods: Drawing from 2 randomized trials, a total of 1,672 patients treated with long EES were analyzed. Of 1,672 patients, 1,061 patients (64{\%}) received post-stent adjunct balloon dilation. MACE, defned as a composite of cardiac death, myocardial infarction, and target-lesion revascularization (TLR), was compared between patients who received post-stent adjunct balloon dilation and patients who did not in 595 propensity scorematched pairs. Results: For the matched population, MACE occurred in 29 patients (4.9{\%}) who received adjunct balloon dilation and in 29 patients (4.9{\%}) who did not (hazard ratio [HR], 1.01; 95{\%} confdence interval [CI], 0.60'1.69; p=0.972). However, signifcant interactions were observed among the subgroups for clinical presentation and vessel size. Adjunct balloon dilation was more favored within the subset of patients with stable angina vs. the subset of patients with acute coronary syndrome (p for interaction=0.037), and within the subset of lesions with small vessel diameter (reference vessel diameter [RVD] <3 mm) vs. the subset of lesions with larger vessel diameter (RVD =3 mm; p for interaction=0.027). Conclusion: Adjunct balloon dilation was not associated with MACE reduction at 1 year among patients requiring long EES implantation. However, post-stent adjunct balloon dilation may be necessary for patients requiring long EES implantation who present with stable angina or for lesions with small vessel diameters.",
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Effect of adjunct balloon dilation after long everolimus-eluting stent deployment on major adverse cardiac events. / Hong, Sung Jin; Ahn, Chul Min; Shin, Dong Ho; Kim, Jung Sun; Kim, Byeong Keuk; Ko, Young Guk; Choi, Donghoon; Her, Ae Young; Kim, Yong Hoon; Jang, Yangsoo; Hong, Myeongki.

In: Korean Circulation Journal, Vol. 47, No. 5, 01.09.2017, p. 694-704.

Research output: Contribution to journalArticle

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T1 - Effect of adjunct balloon dilation after long everolimus-eluting stent deployment on major adverse cardiac events

AU - Hong, Sung Jin

AU - Ahn, Chul Min

AU - Shin, Dong Ho

AU - Kim, Jung Sun

AU - Kim, Byeong Keuk

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Her, Ae Young

AU - Kim, Yong Hoon

AU - Jang, Yangsoo

AU - Hong, Myeongki

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background and Objectives: The effectiveness of adjunct balloon dilation afer drug-eluting stent (DES) deployment has not been sufciently evaluated. We evaluated whether adjunct balloon dilation was associated with a reduction in major adverse cardiac events (MACEs) afer long everolimus-eluting stents (EESs) implantation. Subjects and Methods: Drawing from 2 randomized trials, a total of 1,672 patients treated with long EES were analyzed. Of 1,672 patients, 1,061 patients (64%) received post-stent adjunct balloon dilation. MACE, defned as a composite of cardiac death, myocardial infarction, and target-lesion revascularization (TLR), was compared between patients who received post-stent adjunct balloon dilation and patients who did not in 595 propensity scorematched pairs. Results: For the matched population, MACE occurred in 29 patients (4.9%) who received adjunct balloon dilation and in 29 patients (4.9%) who did not (hazard ratio [HR], 1.01; 95% confdence interval [CI], 0.60'1.69; p=0.972). However, signifcant interactions were observed among the subgroups for clinical presentation and vessel size. Adjunct balloon dilation was more favored within the subset of patients with stable angina vs. the subset of patients with acute coronary syndrome (p for interaction=0.037), and within the subset of lesions with small vessel diameter (reference vessel diameter [RVD] <3 mm) vs. the subset of lesions with larger vessel diameter (RVD =3 mm; p for interaction=0.027). Conclusion: Adjunct balloon dilation was not associated with MACE reduction at 1 year among patients requiring long EES implantation. However, post-stent adjunct balloon dilation may be necessary for patients requiring long EES implantation who present with stable angina or for lesions with small vessel diameters.

AB - Background and Objectives: The effectiveness of adjunct balloon dilation afer drug-eluting stent (DES) deployment has not been sufciently evaluated. We evaluated whether adjunct balloon dilation was associated with a reduction in major adverse cardiac events (MACEs) afer long everolimus-eluting stents (EESs) implantation. Subjects and Methods: Drawing from 2 randomized trials, a total of 1,672 patients treated with long EES were analyzed. Of 1,672 patients, 1,061 patients (64%) received post-stent adjunct balloon dilation. MACE, defned as a composite of cardiac death, myocardial infarction, and target-lesion revascularization (TLR), was compared between patients who received post-stent adjunct balloon dilation and patients who did not in 595 propensity scorematched pairs. Results: For the matched population, MACE occurred in 29 patients (4.9%) who received adjunct balloon dilation and in 29 patients (4.9%) who did not (hazard ratio [HR], 1.01; 95% confdence interval [CI], 0.60'1.69; p=0.972). However, signifcant interactions were observed among the subgroups for clinical presentation and vessel size. Adjunct balloon dilation was more favored within the subset of patients with stable angina vs. the subset of patients with acute coronary syndrome (p for interaction=0.037), and within the subset of lesions with small vessel diameter (reference vessel diameter [RVD] <3 mm) vs. the subset of lesions with larger vessel diameter (RVD =3 mm; p for interaction=0.027). Conclusion: Adjunct balloon dilation was not associated with MACE reduction at 1 year among patients requiring long EES implantation. However, post-stent adjunct balloon dilation may be necessary for patients requiring long EES implantation who present with stable angina or for lesions with small vessel diameters.

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